Awai K, Utsumi T, Kajima T, Fukuda H, Nakamura S, Fujikawa K, Azuma K, Ito K
Department of Medical Imaging, Hiroshima General Hospital.
Nihon Igaku Hoshasen Gakkai Zasshi. 1995 Aug;55(9):633-7.
We studied the early detection of alloxan-induced pulmonary injury by magnetic resonance imaging in vivo. Permeability edema was induced in ten rats by intravenous injection of alloxan at 100 mg/kg. T1-and T2-weighted images were acquired in five rats every 30 min for 120 min after alloxan injection. Five rats served as controls. The rats were sacrificed immediately after imaging and examined microscopically. CT images were also acquired in five rats every 30 min for 120 min after alloxan injection. Five rats served as controls. The rats were sacrificed immediately after imaging, and the wet-to-dry ratio of the lung was measured. In T1-weighted images, relative signal intensity from the lung with permeability edema rose from 30 min to 120 min, and was greater than that from normal lung every time. In T2-weighted images, there was no statistically significant difference in relative signal intensity of the lung between permeability edema and the control during 120 min. In CT images, there was also no statistically significant difference in lung density between permeability edema and the control during 120 min. There was no statistically significant difference in the wet-to-dry lung ratio between edematous lung and normal lung. In histological study, mild congestion and interstitial edema were observed in edematous lung. These results suggest the potential capability of MR imaging in detecting the early phase of permeability pulmonary edema.
我们在体内通过磁共振成像研究了四氧嘧啶诱导的肺损伤的早期检测。通过以100mg/kg的剂量静脉注射四氧嘧啶，在十只大鼠中诱导通透性水肿。在注射四氧嘧啶后，对五只大鼠每隔30分钟采集一次T1加权和T2加权图像，共采集120分钟。五只大鼠作为对照。成像后立即处死大鼠并进行显微镜检查。在注射四氧嘧啶后，也对五只大鼠每隔30分钟采集一次CT图像，共采集120分钟。五只大鼠作为对照。成像后立即处死大鼠，并测量肺的湿干比。在T1加权图像中，有通透性水肿的肺的相对信号强度从30分钟到120分钟升高，并且每次都大于正常肺的相对信号强度。在T2加权图像中，在120分钟内，有通透性水肿的肺与对照的相对信号强度在统计学上没有显著差异。在CT图像中，在120分钟内，有通透性水肿的肺与对照的肺密度在统计学上也没有显著差异。水肿肺与正常肺的肺湿干比在统计学上没有显著差异。在组织学研究中，在水肿肺中观察到轻度充血和间质水肿。这些结果表明磁共振成像在检测通透性肺水肿早期阶段的潜在能力。
