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术中噬菌体疗法成功治疗顽固性人工膝关节感染

Successful Treatment of a Recalcitrant Prosthetic Knee Infection with Intraoperative Bacteriophage Therapy.

作者信息

Doub James B, Ng Vincent Y, Wilson Eleanor, Corsini Lorenzo, Chan Benjamin K

机构信息

Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Department of Orthopedic Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

出版信息

Pharmaceuticals (Basel). 2021 Mar 8;14(3):231. doi: 10.3390/ph14030231.

DOI:10.3390/ph14030231
PMID:33800146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7998749/
Abstract

Here, we present a case of a 79-year-old female with a recalcitrant prosthetic knee infection that was successfully treated with a single dose of adjuvant intra-articular bacteriophage therapy after debridement and implant retention surgery. The bacteriophage used in this case, PM448, is the first ɛ bacteriophage to be used in vivo. Currently the patient is without evidence of clinical recurrence and, interestingly, the patient had also suffered from debilitating aplastic anemia for over 2 years, which is recovering since receiving adjuvant bacteriophage therapy.

摘要

在此，我们报告一例79岁女性难治性人工膝关节感染病例，该患者在清创及植入物保留手术后，经单剂量关节内辅助噬菌体治疗成功治愈。本病例中使用的噬菌体PM448是首个用于体内的ε噬菌体。目前患者无临床复发迹象，有趣的是，该患者还患有严重再生障碍性贫血超过两年，自接受辅助噬菌体治疗后病情正在恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/5e7fdce66e04/pharmaceuticals-14-00231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/44a2fc556d71/pharmaceuticals-14-00231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/56572ce5e68c/pharmaceuticals-14-00231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/5e7fdce66e04/pharmaceuticals-14-00231-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/44a2fc556d71/pharmaceuticals-14-00231-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/56572ce5e68c/pharmaceuticals-14-00231-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/740c/7998749/5e7fdce66e04/pharmaceuticals-14-00231-g003.jpg

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Front Med (Lausanne). 2020 Nov 16;7:570572. doi: 10.3389/fmed.2020.570572. eCollection 2020.
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Antibiotics (Basel). 2020 Nov 12;9(11):799. doi: 10.3390/antibiotics9110799.
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Debridement, antibiotics and implant retention (DAIR) for the management of knee prosthetic joint infection.
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Front Microbiol. 2025 Feb 24;16:1553979. doi: 10.3389/fmicb.2025.1553979. eCollection 2025.
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