Dimitrakopoulos Foteinos-Ioannis, Koliou Georgia-Angeliki, Kotoula Vassiliki, Papadopoulou Kyriaki, Markou Konstantinos, Vlachtsis Konstantinos, Angouridakis Nikolaos, Karasmanis Ilias, Nikolaou Angelos, Psyrri Amanda, Visvikis Anastasios, Kosmidis Paris, Fountzilas George, Koutras Angelos
Division of Oncology & Molecular Oncology Laboratory, Department of Medicine, University Hospital, Medical School, University of Patras, 26504 Patras, Greece.
Section of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, 11526 Athens, Greece.
Cancers (Basel). 2021 Mar 8;13(5):1163. doi: 10.3390/cancers13051163.
Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes (, , and ) were evaluated regarding their clinical significance in HNC patients. In total, 333 HNC patients were enrolled in this study and 34 variants located on the aforementioned genes were genotyped via Sanger sequencing. LC patients, homozygous A for rs13207351, had shorter overall survival (OS) as opposed to homozygous G (Hazard ratio (HR) = 2.06, Wald's 0.017) upon adjustment for age, disease stage, and surgery. Following the dominant model, LC patients carrying the A allele had a marginally significantly higher risk for death (HR = 1.72, = 0.059). NPC patients heterozygous (CT) for rs2234768 had a marginal but significantly higher risk of death compared to those with homozygosity for the T allele (HR = 2.22, = 0.056). In conclusion, rs13207351 () and rs2234768 () polymorphisms seem to have prognostic significance in HNC, with rs13207351 showing the most promise in this subgroup of LC patients.
头颈癌（HNC）是一种异质性显著的疾病，包括源自不同解剖部位的恶性肿瘤，如鼻咽癌（NPC）和喉癌（LC）。在本研究中，对血管生成和凋亡相关基因（、、和）中的多态性在HNC患者中的临床意义进行了评估。本研究共纳入333例HNC患者，并通过桑格测序对上述基因上的34个变异进行基因分型。在对年龄、疾病分期和手术进行调整后，rs13207351纯合A的LC患者与纯合G患者相比总生存期（OS）更短（风险比（HR）=2.06，Wald检验P=0.017）。按照显性模型，携带A等位基因的LC患者死亡风险略高（HR=1.72，P=0.059）。rs2234768杂合（CT）的NPC患者与T等位基因纯合患者相比死亡风险略高但具有统计学意义（HR=2.22，P=0.056）。总之，rs13207351（）和rs2234768（）多态性似乎在HNC中具有预后意义，rs13207351在该LC患者亚组中显示出最大前景。
