Di Benedetto Giorgia, Parisi Silvia, Russo Tommaso, Passaro Fabiana
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 40, 80138 Napoli, Italy.
Metabolites. 2021 Mar 8;11(3):154. doi: 10.3390/metabo11030154.
Cell reprogramming can either refer to a direct conversion of a specialized cell into another or to a reversal of a somatic cell into an induced pluripotent stem cell (iPSC). It implies a peculiar modification of the epigenetic asset and gene regulatory networks needed for a new cell, to better fit the new phenotype of the incoming cell type. Cellular reprogramming also implies a metabolic rearrangement, similar to that observed upon tumorigenesis, with a transition from oxidative phosphorylation to aerobic glycolysis. The induction of a reprogramming process requires a nexus of signaling pathways, mixing a range of local and systemic information, and accumulating evidence points to the crucial role exerted by the Hippo pathway components Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ). In this review, we will first provide a synopsis of the Hippo pathway and its function during reprogramming and tissue regeneration, then we introduce the latest knowledge on the interplay between YAP/TAZ and metabolism and, finally, we discuss the possible role of YAP/TAZ in the orchestration of the metabolic switch upon cellular reprogramming.
细胞重编程既可以指将一种特化细胞直接转化为另一种细胞，也可以指将体细胞逆转为诱导多能干细胞（iPSC）。这意味着对新细胞所需的表观遗传特征和基因调控网络进行特殊修饰，以更好地适应新进入细胞类型的新表型。细胞重编程还意味着代谢重排，类似于在肿瘤发生过程中观察到的情况，即从氧化磷酸化转变为有氧糖酵解。重编程过程的诱导需要一系列信号通路的关联，整合一系列局部和全身信息，并且越来越多的证据表明，Hippo信号通路的组成部分Yes相关蛋白（YAP）和含PDZ结合基序的转录共激活因子（TAZ）发挥着关键作用。在这篇综述中，我们首先将概述Hippo信号通路及其在重编程和组织再生过程中的功能，然后介绍关于YAP/TAZ与代谢之间相互作用的最新知识，最后讨论YAP/TAZ在细胞重编程过程中协调代谢转换的可能作用。
