Park Ye Lin, Park Kiwon, Cha Jae Min
Department of Mechatronics Engineering, College of Engineering, Incheon National University, Incheon 22012, Korea.
3D Stem Cell Bioengineering Laboratory, Research Institute for Engineering and Technology, Incheon National University, Incheon 22012, Korea.
Micromachines (Basel). 2021 Mar 8;12(3):287. doi: 10.3390/mi12030287.
Over the past decades, a number of bone tissue engineering (BTE) approaches have been developed to address substantial challenges in the management of critical size bone defects. Although the majority of BTE strategies developed in the laboratory have been limited due to lack of clinical relevance in translation, primary prerequisites for the construction of vascularized functional bone grafts have gained confidence owing to the accumulated knowledge of the osteogenic, osteoinductive, and osteoconductive properties of mesenchymal stem cells and bone-relevant biomaterials that reflect bone-healing mechanisms. In this review, we summarize the current knowledge of bone-healing mechanisms focusing on the details that should be embodied in the development of vascularized BTE, and discuss promising strategies based on 3D-bioprinting technologies that efficiently coalesce the abovementioned main features in bone-healing systems, which comprehensively interact during the bone regeneration processes.
在过去几十年里，已经开发了多种骨组织工程（BTE）方法来应对大尺寸骨缺损治疗中的重大挑战。尽管实验室中开发的大多数BTE策略由于在转化过程中缺乏临床相关性而受到限制，但由于对间充质干细胞和成骨、骨诱导及骨传导特性的骨相关生物材料的累积认识反映了骨愈合机制，构建血管化功能性骨移植物的主要先决条件已获得信心。在这篇综述中，我们总结了骨愈合机制的当前知识，重点关注血管化BTE开发中应体现的细节，并讨论基于3D生物打印技术的有前景的策略，这些策略能有效地将上述骨愈合系统的主要特征融合在一起，它们在骨再生过程中全面相互作用。
