Quintanilla-Sierra L, García-Arévalo C, Rodriguez-Cabello J C
BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, 47011, Valladolid, Spain.
Mater Today Bio. 2019 May 20;2:100007. doi: 10.1016/j.mtbio.2019.100007. eCollection 2019 Mar.
The topic of self-assembled structures based on elastin-like recombinamers (ELRs, i.e., elastin-like polymers recombinantly bio-produced) has released a noticeable amount of references in the last few years. Most of them are intended for biomedical applications. In this review, a complete revision of the bibliography is carried out. Initially, the self-assembly (SA) concept is considered from a general point of view, and then ELRs are described and characterized based on their intrinsic disorder. A classification of the different self-assembled ELR-based structures is proposed based on their morphologies, paying special attention to their tentative modeling. The impact of the mechanism of SA on these biomaterials is analyzed. Finally, the implications of ELR SA in biological systems are considered.
基于类弹性蛋白重组蛋白（即通过重组生物生产的类弹性蛋白聚合物）的自组装结构这一主题在过去几年中已发表了大量参考文献。其中大多数都用于生物医学应用。在本综述中，对相关文献进行了全面修订。首先，从一般角度考虑自组装（SA）概念，然后基于其内在无序性对类弹性蛋白重组蛋白进行描述和表征。根据不同基于类弹性蛋白重组蛋白的自组装结构的形态提出了一种分类方法，并特别关注其初步建模。分析了自组装机制对这些生物材料的影响。最后，考虑了类弹性蛋白重组蛋白自组装在生物系统中的意义。
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