International Institute 'Solution Chemistry of Advanced Materials and Technologies', ITMO University, 191002 Saint-Petersburg, Russia.
Institute of Gene Biology, Russian Academy of Science, 119334 Moscow, Russia.
Int J Mol Sci. 2021 Mar 6;22(5):2662. doi: 10.3390/ijms22052662.
Tumor-associated macrophages (TAMs) are the essential components of the tumor microenvironment. TAMs originate from blood monocytes and undergo pro- or anti-inflammatory polarization during their life span within the tumor. The balance between macrophage functional populations and the efficacy of their antitumor activities rely on the transcription factors such as STAT1, NF-κB, IRF, and others. These molecular tools are of primary importance, as they contribute to the tumor adaptations and resistance to radio- and chemotherapy and can become important biomarkers for theranostics. Herein, we describe the major transcriptional mechanisms specific for TAM, as well as how radio- and chemotherapy can impact gene transcription and functionality of macrophages, and what are the consequences of the TAM-tumor cooperation.
肿瘤相关巨噬细胞（TAMs）是肿瘤微环境的重要组成部分。TAMs 来源于血液单核细胞，并在肿瘤内的寿命期间经历促炎或抗炎极化。巨噬细胞功能群体之间的平衡及其抗肿瘤活性的功效依赖于转录因子，如 STAT1、NF-κB、IRF 等。这些分子工具非常重要，因为它们有助于肿瘤的适应和对放化疗的抵抗，并可能成为治疗诊断的重要生物标志物。在此，我们描述了 TAM 特有的主要转录机制，以及放化疗如何影响巨噬细胞的基因转录和功能，以及 TAM-肿瘤合作的后果是什么。
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