Cancer Biology & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata, WB 700032, India.
Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, WB 700026, India.
Int J Mol Sci. 2020 Sep 27;21(19):7117. doi: 10.3390/ijms21197117.
Emerging shreds of evidence suggest that tumor-associated macrophages (TAMs) modulate various hallmarks of cancer during tumor progression. Tumor microenvironment (TME) prime TAMs to execute important roles in cancer development and progression, including angiogenesis, matrix metalloproteinases (MMPs) secretion, and extracellular matrix (ECM) disruption. MicroRNAs (miRNAs) are critical epigenetic regulators, which modulate various functions in diverse types of cells, including macrophages associated with TME. In this review article, we provide an update on miRNAs regulating differentiation, maturation, activation, polarization, and recruitment of macrophages in the TME. Furthermore, extracellular miRNAs are secreted from cancerous cells, which control macrophages phenotypic plasticity to support tumor growth. In return, TAMs also secrete various miRNAs that regulate tumor growth. Herein, we also describe the recent updates on the molecular connection between tumor cells and macrophages. A better understanding of the interaction between miRNAs and TAMs will provide new pharmacological targets to combat cancer.
新兴的证据表明，肿瘤相关巨噬细胞（TAMs）在肿瘤进展过程中调节癌症的各种特征。肿瘤微环境（TME）使 TAMs 能够在癌症的发生和发展中发挥重要作用，包括血管生成、基质金属蛋白酶（MMPs）的分泌和细胞外基质（ECM）的破坏。microRNAs（miRNAs）是重要的表观遗传调控因子，调节包括与 TME 相关的巨噬细胞在内的多种类型细胞的各种功能。在这篇综述文章中，我们提供了关于 miRNAs 调节 TME 中巨噬细胞分化、成熟、激活、极化和募集的最新信息。此外，癌细胞分泌的细胞外 miRNAs 控制巨噬细胞表型可塑性以支持肿瘤生长。反过来，TAMs 也分泌各种调节肿瘤生长的 miRNAs。本文还描述了肿瘤细胞与巨噬细胞之间分子联系的最新进展。更好地理解 miRNAs 和 TAMs 之间的相互作用将为对抗癌症提供新的药物靶点。
