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海洋真菌生物活性物质具有抗炎、抗血栓和抗氧化特性,可促进与炎症相关的慢性疾病的健康。

Marine Fungi Bioactives with Anti-Inflammatory, Antithrombotic and Antioxidant Health-Promoting Properties Against Inflammation-Related Chronic Diseases.

机构信息

Hephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala University Campus, St. Lucas, 65404 Kavala, Greece.

Fisheries Research Institute, Nea Peramos, 64007 Kavala, Greece.

出版信息

Mar Drugs. 2024 Nov 18;22(11):520. doi: 10.3390/md22110520.

Abstract

Fungi play a fundamental role in the marine environment, being promising producers of bioactive molecules in the pharmacological and industrial fields, which have demonstrated potential health benefits against cardiovascular and other chronic diseases. This review pertains to the analysis of the lipid compositions across various species of marine fungi and their constantly discovered substances, as well as their anti-inflammatory, antioxidant, and antithrombotic effects. The health-promoting aspects of these microorganisms will be explored, through the investigation of several mechanisms of action and interference of their bioactives in biochemical pathways. Despite exceptional results in this field, the potential of marine microorganisms remains largely unexplored due to the limited number of specialists in marine microbiology and mycology, a relatively recent science with significant contributions and potential in biodiversity and biotechnology.

摘要

真菌在海洋环境中发挥着重要作用,是药理学和工业领域中具有生物活性分子的有前途的生产者,这些分子已被证明对心血管和其他慢性疾病具有潜在的健康益处。本综述涉及对各种海洋真菌物种的脂质成分及其不断发现的物质进行分析,以及它们的抗炎、抗氧化和抗血栓作用。通过研究其生物活性物质在生化途径中的作用机制和干扰作用,将探讨这些微生物的促进健康方面。尽管在这一领域取得了非凡的成果,但由于海洋微生物学和真菌学方面的专家数量有限,以及这一相对较新的科学在生物多样性和生物技术方面的重要贡献和潜力,海洋微生物的潜力在很大程度上仍未得到探索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d50/11595437/f83894ef2f58/marinedrugs-22-00520-g001a.jpg

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