使用可穿戴生物传感器评估多发性硬化症残疾进展：一项试点研究。
Assessment of Multiple Sclerosis Disability Progression Using a Wearable Biosensor: A Pilot Study.
作者信息
Abbadessa Gianmarco, Lavorgna Luigi, Miele Giuseppina, Mignone Alfredo, Signoriello Elisabetta, Lus Giacomo, Clerico Marinella, Sparaco Maddalena, Bonavita Simona
机构信息
Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
University of Turin, 10126 Torino, Italy.
出版信息
J Clin Med. 2021 Mar 10;10(6):1160. doi: 10.3390/jcm10061160.
BACKGROUND
The evaluation of walking activity of people with multiple sclerosis (pwMS) is desirable. We evaluate the power of the correlation of motor parameters detected by the accelerometer in the Samsung Gear S2 smartwatch with multiple sclerosis (MS) disability measures and patient reported outcomes (PROs).
METHODS
We enrolled 25 relapsing remitting MS patients. We assessed disability with the expanded disability status scale, two-minute walking test (2MWT), timed 25-foot walk test (T25FWT), and nine-hole peg test. We collected PROs measuring fatigue, ambulatory ability, depression, quality of life, and bladder/bowel function. Participants were asked to wear the accelerometer for a period of 30 days.
RESULTS
The Spearman's rank correlation coefficient showed a moderate negative correlation between the patient-determined disease steps (PDDS) score with the mean steps/day, a strong negative correlation between the PDDS score with the maximum number of daily steps (MNDS) and a moderate negative correlation between the fatigue severity scale score and MNDS. A moderate negative correlation between MNDS and the 2MWT and a moderate negative correlation between MNDS and the T25FW was found.
CONCLUSION
Our results suggest that motor parameters derived from the accelerometer could be a reliable measure of motor disability in pwMS.
背景
对多发性硬化症患者（pwMS）的步行活动进行评估很有必要。我们评估了三星Gear S2智能手表中的加速度计检测到的运动参数与多发性硬化症（MS）残疾指标和患者报告结局（PROs）之间的相关性强度。
方法
我们招募了25名复发缓解型MS患者。我们用扩展残疾状态量表、两分钟步行测试（2MWT）、25英尺定时步行测试（T25FWT）和九孔插板测试来评估残疾情况。我们收集了测量疲劳、步行能力、抑郁、生活质量以及膀胱/肠道功能的PROs。参与者被要求佩戴加速度计30天。
结果
斯皮尔曼等级相关系数显示，患者确定的疾病步数（PDDS）得分与日均步数之间呈中度负相关，PDDS得分与每日最大步数（MNDS）之间呈强负相关，疲劳严重程度量表得分与MNDS之间呈中度负相关。发现MNDS与2MWT之间呈中度负相关以及MNDS与T25FW之间呈中度负相关。
结论
我们的结果表明，来自加速度计的运动参数可能是pwMS运动残疾的可靠指标。
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