Cojocaru Alexandru, Burada Emilia, Bălșeanu Adrian-Tudor, Deftu Alexandru-Florian, Cătălin Bogdan, Popa-Wagner Aurel, Osiac Eugen
Department of Physiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
J Clin Med. 2021 Mar 17;10(6):1239. doi: 10.3390/jcm10061239.
As the average age and life expectancy increases, the incidence of both acute and chronic central nervous system (CNS) pathologies will increase. Understanding mechanisms underlying neuroinflammation as the common feature of any neurodegenerative pathology, we can exploit the pharmacology of cell specific ion channels to improve the outcome of many CNS diseases. As the main cellular player of neuroinflammation, microglia play a central role in this process. Although microglia are considered non-excitable cells, they express a variety of ion channels under both physiological and pathological conditions that seem to be involved in a plethora of cellular processes. Here, we discuss the impact of modulating microglia voltage-gated, potential transient receptor, chloride and proton channels on microglial proliferation, migration, and phagocytosis in neurodegenerative diseases.
随着平均年龄和预期寿命的增加，急性和慢性中枢神经系统（CNS）疾病的发病率将会上升。鉴于神经炎症是任何神经退行性疾病的共同特征，了解其潜在机制后，我们可以利用细胞特异性离子通道的药理学来改善许多中枢神经系统疾病的治疗效果。作为神经炎症的主要细胞参与者，小胶质细胞在这一过程中起着核心作用。尽管小胶质细胞被认为是不可兴奋细胞，但在生理和病理条件下，它们都表达多种离子通道，这些离子通道似乎参与了众多细胞过程。在此，我们讨论调节小胶质细胞电压门控通道、潜在瞬时受体通道、氯离子通道和质子通道对神经退行性疾病中小胶质细胞增殖、迁移和吞噬作用的影响。
