Smith Lee, Veronese Nicola, López-Sánchez Guillermo F, Yang Lin, Pizzol Damiano, Butler Laurie T, Barnett Yvonne, Felez-Nobrega Mireia, Jacob Louis, Shin Jae Il, Tully Mark A, Gorely Trish, Oh Hans, Koyanagi Ai
The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge CB1 1PT, UK.
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90133 Palermo, Italy.
J Clin Med. 2021 Mar 17;10(6):1243. doi: 10.3390/jcm10061243.
Active travel may be an easily achievable form of physical activity for older people especially in low- and middle-income countries (LMICs), but there are currently no studies on how this form of physical activity is associated with a preclinical state of dementia known as mild cognitive impairment (MCI). Therefore, we aimed to investigate the association between active travel and MCI among adults aged ≥50 years from six LMICs. Cross-sectional, community-based data from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. The definition of MCI was based on the National Institute on Ageing-Alzheimer's Association criteria. Active travel (minutes/week) was assessed with questions of the Global Physical Activity Questionnaire (GPAQ) and presented in tertiles. Multivariable logistic regression analysis was conducted to assess the association between active travel and MCI. Data on 32715 people aged ≥50 years (mean age 62.4 years; 52.1% females) were analyzed. Compared to the highest tertile of active travel, the lowest tertile was associated with 1.33 (95%CI = 1.14-1.54) times higher odds for MCI overall. This association was particularly pronounced among those aged ≥65 years (OR = 1.70; 95%CI = 1.32-2.19) but active travel was not associated with MCI among those aged 50-64 years. In conclusion, low levels of active travel were associated with a significantly higher odds of MCI in adults aged ≥65 years in LMICs. Promoting active travel among people of this age group in LMICs via tailored interventions and/or country-wide infrastructure investment to provide a safe environment for active travel may lead to a reduction in MCI and subsequent dementia.
主动出行对于老年人来说可能是一种易于实现的身体活动形式，尤其是在低收入和中等收入国家（LMICs），但目前尚无关于这种身体活动形式与一种称为轻度认知障碍（MCI）的痴呆症临床前状态之间关联的研究。因此，我们旨在调查来自六个低收入和中等收入国家的50岁及以上成年人中主动出行与MCI之间的关联。对世界卫生组织全球老龄化与成人健康研究的横断面、基于社区的数据进行了分析。MCI的定义基于美国国立衰老研究所 - 阿尔茨海默病协会的标准。通过全球身体活动问卷（GPAQ）的问题评估主动出行（分钟/周），并将其分为三个三分位数。进行多变量逻辑回归分析以评估主动出行与MCI之间的关联。分析了32715名50岁及以上人群（平均年龄62.4岁；52.1%为女性）的数据。与主动出行最高三分位数相比，最低三分位数与MCI总体患病几率高1.33倍（95%置信区间 = 1.14 - 1.54）相关。这种关联在65岁及以上人群中尤为明显（比值比 = 1.70；95%置信区间 = 1.32 - 2.19），但在50 - 64岁人群中主动出行与MCI无关。总之，在低收入和中等收入国家，65岁及以上成年人中主动出行水平低与MCI患病几率显著较高相关。通过量身定制的干预措施和/或全国范围的基础设施投资，在低收入和中等收入国家的这一年龄组人群中促进主动出行，以提供安全的主动出行环境，可能会导致MCI及后续痴呆症的减少。
