França Sérgio Lobato, Oliveira Rodrigo Santos de, Sousa Gabriel Silas Marinho, Sá Sarah Rodrigues de, Nogueira Walber da Silva, Santo Elaine Patrícia Tavares do Espírito, Caldas Daniel Dos Santos, Silva Silvia Helena Marques da
Hospital Universitário João de Barros Barreto, Belém 66073-000, Pará, Brazil.
Programa de Pós-Graduação em Biologia de Agentes Infecciosos e Parasitários, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, Pará, Brazil.
J Fungi (Basel). 2025 May 20;11(5):394. doi: 10.3390/jof11050394.
This study included 24 isolates of the species complex from patients in the Brazilian Amazon between 2021 and 2024. These isolates were identified by sequencing as (54.2%), sensu stricto (29.2%), var. (12.5%), and (4.2%). The finding of represents the first case reported in Brazil. Haplotype and phylogenetic analysis of these species, along with other isolates from Brazil, revealed low intraspecific genetic diversity. Resistance to at least one antifungal was observed in 83.3% of isolates, with multidrug resistance in 58.3%, including one isolate resistant to all tested antifungals. The isolates demonstrated active biofilm production, lytic enzyme activity, and thermotolerance. Notably, one isolate exhibited tolerance to 42 °C, a phenotype not previously described. It is crucial for Brazil and other countries to recognize the emergence of these species as a public health threat and to take proactive measures to prevent outbreaks.
本研究纳入了2021年至2024年间从巴西亚马逊地区患者中分离出的24株该菌种复合体。通过测序将这些分离株鉴定为（54.2%）、狭义（29.2%）、变种（12.5%）和（4.2%）。的发现代表了巴西报告的首例病例。对这些菌种以及来自巴西的其他分离株进行单倍型和系统发育分析，结果显示种内遗传多样性较低。在83.3%的分离株中观察到对至少一种抗真菌药物耐药，58.3%的分离株存在多重耐药，其中一株对所有测试抗真菌药物均耐药。这些分离株表现出活跃的生物膜形成、裂解酶活性和耐热性。值得注意的是，一株分离株表现出对42℃的耐受性，这是一种此前未描述过的表型。巴西和其他国家必须认识到这些菌种的出现对公共卫生构成的威胁，并采取积极措施预防疫情爆发。
