IOC-Instituto do Osso e da Cartilagem, 1386 Presidente Kennedy Avenue, Indaiatuba 13334-170, Brazil.
Orthopaedic Department-UNIFESP/EPM, 715 Napoleão de Barros St, São Paulo 04024-002, Brazil.
Int J Mol Sci. 2021 Mar 9;22(5):2762. doi: 10.3390/ijms22052762.
The rise in musculoskeletal disorders has prompted medical experts to devise novel effective alternatives to treat complicated orthopedic conditions. The ever-expanding field of regenerative medicine has allowed researchers to appreciate the therapeutic value of bone marrow-derived biological products, such as the bone marrow aspirate (BMA) clot, a potent orthobiologic which has often been dismissed and regarded as a technical complication. Numerous in vitro and in vivo studies have contributed to the expansion of medical knowledge, revealing optimistic results concerning the application of autologous bone marrow towards various impactful disorders. The bone marrow accommodates a diverse family of cell populations and a rich secretome; therefore, autologous BMA-derived products such as the "BMA Matrix", may represent a safe and viable approach, able to reduce the costs and some drawbacks linked to the expansion of bone marrow. BMA provides -it eliminates many hurdles associated with its preparation, especially in regards to regulatory compliance. The BMA Matrix represents a suitable alternative, indicated for the enhancement of tissue repair mechanisms by modulating inflammation and acting as a natural biological scaffold as well as a reservoir of cytokines and growth factors that support cell activity. Although promising, more clinical studies are warranted in order to further clarify the efficacy of this strategy.
肌肉骨骼疾病的增加促使医学专家设计出新颖有效的替代方法来治疗复杂的骨科疾病。不断扩大的再生医学领域使研究人员认识到骨髓源性生物产品的治疗价值，例如骨髓抽吸（BMA）凝块，这是一种有效的骨生物制剂，常常被忽视，并被视为一种技术并发症。大量的体外和体内研究为医学知识的扩展做出了贡献，揭示了自体骨髓在各种有影响力的疾病中的应用的乐观结果。骨髓容纳了多种细胞群体和丰富的分泌组；因此，自体 BMA 衍生产品，如“BMA 基质”，可能代表一种安全可行的方法，能够降低与骨髓扩增相关的成本和一些缺点。BMA 提供了——它消除了与其制备相关的许多障碍，特别是在监管合规方面。BMA 基质是一种合适的替代品，通过调节炎症来增强组织修复机制，作为天然的生物支架，并作为细胞因子和生长因子的储存库，支持细胞活性。尽管有希望，但需要更多的临床研究来进一步阐明这一策略的疗效。
