Nieto-Sampedro M, Lim R, Hicklin D J, Cotman C W
Department of Psychobiology, University of California, Irvine 92717.
Neurosci Lett. 1988 Apr 12;86(3):361-5. doi: 10.1016/0304-3940(88)90511-3.
A major component of the healing response of the brain to injury is the induction of growth and trophic factors. In the rat brain, glia maturation factor (GMF) and acidic fibroblast growth factor (aFGF) are not extracellular. However, within the first hour following brain injury, the amount of GMF and aFGF in the wound cavity increased by 7- and 13-fold, respectively, compared to the tissue adjacent to the wound. A cascade of cellular and biochemical events, leading to glial proliferation, the arrest of secondary neuronal death and axonal sprouting, may be initiated by the sudden increase in the extracellular concentration of these factors.
大脑对损伤的愈合反应的一个主要组成部分是生长因子和营养因子的诱导。在大鼠大脑中，神经胶质成熟因子（GMF）和酸性成纤维细胞生长因子（aFGF）并非存在于细胞外。然而，在脑损伤后的第一个小时内，与伤口相邻的组织相比，伤口腔内的GMF和aFGF含量分别增加了7倍和13倍。这些因子细胞外浓度的突然增加可能引发一系列细胞和生化事件，导致神经胶质细胞增殖、继发性神经元死亡的停止以及轴突发芽。
