Giordano Vito, Goeral Katharina, Schrage-Leitner Leslie, Berger Angelika, Olischar Monika
Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.
Department of Music Therapy, University of Music and Performing Arts, Seilerstätte 26, 1010 Vienna, Austria.
Children (Basel). 2021 Mar 9;8(3):208. doi: 10.3390/children8030208.
Several methods can be used in the neonatal intensive care unit (NICU) to reduce stress and optimize the quality of life during this period of hospitalization. Among these, music could play an important role. We investigated the effect of different kinds of music therapies on the brain activity of very preterm infants using amplitude-integrated EEG. Sixty-four patients were included and randomly assigned to three different groups: live music group, recorded music group, and control group. In both intervention groups, music was started after the appearance of the first quiet-sleep phase, with a subsequent duration of 20 min. Changes between the first and second quiet-sleep epochs were analyzed using the amplitude-integrated EEG. When looking at single parameters of the amplitude-integrated EEG trace, no differences could be found between the groups when comparing their first and second quiet-sleep phase regarding the parameters of change from baseline, quality of the quiet-sleep epoch, and duration. However, when looking at the total cyclicity score of the second quiet-sleep phase, a difference between both intervention groups and the control group could be found (live music therapy vs. control, = 0.003; recorded music therapy vs. control, = 0.006). Improvement within the first and second quiet-sleep epochs were detected in both music groups, but not in the control group. We concluded that our study added evidence of the beneficial effect of music on the amplitude-integrated EEG activity in preterm infants.
新生儿重症监护病房（NICU）可采用多种方法来减轻压力并优化住院期间的生活质量。其中，音乐可能发挥重要作用。我们使用振幅整合脑电图研究了不同种类音乐疗法对极早产儿脑活动的影响。纳入了64名患者，并将其随机分为三组：现场音乐组、录制音乐组和对照组。在两个干预组中，音乐在第一个安静睡眠期出现后开始播放，持续20分钟。使用振幅整合脑电图分析第一个和第二个安静睡眠期之间的变化。当查看振幅整合脑电图轨迹的单个参数时，在比较各组第一个和第二个安静睡眠期的基线变化参数、安静睡眠期质量和持续时间时，未发现组间差异。然而，当查看第二个安静睡眠期的总周期性评分时，发现两个干预组与对照组之间存在差异（现场音乐疗法与对照组相比，P = 0.003；录制音乐疗法与对照组相比，P = 0.006）。两个音乐组在第一个和第二个安静睡眠期均有改善，但对照组没有。我们得出结论，我们的研究增加了音乐对早产儿振幅整合脑电图活动有益影响的证据。
