Goumard Claire, Turco Célia, Sakka Mehdi, Aoudjehane Lynda, Lesnik Philippe, Savier Eric, Conti Filomena, Scatton Olivier
Department of Hepatobiliary Surgery and Liver Transplantation, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance Publique-Hopitaux de Paris, 75013 Paris, France.
Sorbonne Université, Centre de Recherche Saint Antoine, INSERM UMRS-938, Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, France.
J Clin Med. 2021 Mar 18;10(6):1253. doi: 10.3390/jcm10061253.
The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model.
持续的器官短缺迫使移植团队开发肝脏移植的替代来源。在这种情况下，异位机器灌注作为一种有前景的工具迅速发展，用于评估扩大标准供体器官（包括脂肪肝移植物）的活力并改善其功能。特别是，常温机器灌注是一种强大的工具，可在37°C的全代谢状态下测试肝脏，并在需要时进行药理学纠正。在此背景下，人们已经测试了许多药物和治疗方法，以在常温机器灌注时诱导肝脏去脂，即使在人体器官上也取得了有希望的结果。本系统评价对现有的肝脏去脂药物疗法进行了全面综述，特别关注常温肝脏机器灌注作为一种实验性体外转化模型。
