Baukova Alexandra, Bogun Alexander, Sushkova Svetlana, Minkina Tatiana, Mandzhieva Saglara, Alliluev Ilya, Jatav Hanuman Singh, Kalinitchenko Valery, Rajput Vishnu D, Delegan Yanina
Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center "Pushchino Scientific Center for Biological Research of Russian Academy of Sciences" (FRC PSCBR RAS), 142290 Pushchino, Moscow Region, Russia.
Pushchino Branch of Federal State Budgetary Educational Institution of Higher Education "Russian Biotechnology University (ROSBIOTECH)", 142290 Pushchino, Moscow Region, Russia.
Antibiotics (Basel). 2024 Jun 27;13(7):597. doi: 10.3390/antibiotics13070597.
bacteria are renowned for their remarkable capacity to synthesize antibiotics, namely mupirocin, gluconic acid, pyrrolnitrin, and 2,4-diacetylphloroglucinol (DAPG). While these substances are extensively employed in agricultural biotechnology to safeguard plants against harmful bacteria and fungi, their potential for human medicine and healthcare remains highly promising for common science. However, the challenge of obtaining stable producers that yield higher quantities of these antibiotics continues to be a pertinent concern in modern biotechnology. Although the interest in antibiotics of bacteria has persisted over the past century, many uncertainties still surround the regulation of the biosynthetic pathways of these compounds. Thus, the present review comprehensively studies the genetic organization and regulation of the biosynthesis of these antibiotics and provides a comprehensive summary of the genetic organization of antibiotic biosynthesis pathways in pseudomonas strains, appealing to both molecular biologists and biotechnologists. In addition, attention is also paid to the application of antibiotics in plant protection.
细菌以其合成抗生素的卓越能力而闻名，这些抗生素包括莫匹罗星、葡萄糖酸、吡咯菌素和2,4-二乙酰基间苯三酚（DAPG）。虽然这些物质在农业生物技术中被广泛用于保护植物免受有害细菌和真菌的侵害，但它们在人类医学和医疗保健方面的潜力对于普通科学来说仍然非常有前景。然而，获得能够大量生产这些抗生素的稳定生产者的挑战，仍然是现代生物技术中一个相关的问题。尽管在过去的一个世纪里，人们对细菌抗生素的兴趣一直存在，但这些化合物生物合成途径的调控仍存在许多不确定性。因此，本综述全面研究了这些抗生素生物合成的遗传组织和调控，并对假单胞菌菌株中抗生素生物合成途径的遗传组织进行了全面总结，这对分子生物学家和生物技术专家都有吸引力。此外，还关注了抗生素在植物保护中的应用。
