Department of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
Department of Chemistry of Biomaterials and Cosmetics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
Int J Mol Sci. 2021 Mar 24;22(7):3329. doi: 10.3390/ijms22073329.
Hydrogels based on chitosan are very versatile materials which can be used for tissue engineering as well as in controlled drug delivery systems. One of the methods for obtaining a chitosan-based hydrogel is crosslinking by applying different components. The objective of the present study was to obtain a series of new crosslinked chitosan-based films by means of solvent casting method. Squaric acid-3,4-dihydroxy-3-cyclobutene-1,2-dione-was used as a safe crosslinking agent. The effect of the squaric acid on the structural, mechanical, thermal, and swelling properties of the formed films was determined. It was established that the addition of the squaric acid significantly improved Young's modulus, tensile strength, and thermal stability of the obtained materials. Moreover, it should be stressed that the samples consisting of chitosan and squaric acid were characterized by a higher swelling than pure chitosan. The detailed characterization proved that squaric acid could be used as a new effective crosslinking agent.
基于壳聚糖的水凝胶是非常通用的材料，可用于组织工程以及控制药物释放系统。获得壳聚糖水凝胶的一种方法是通过应用不同的成分进行交联。本研究的目的是通过溶剂浇铸法获得一系列新型交联壳聚糖基薄膜。3,4-二羟基-3-环丁烯-1,2-二酮-均苯三甲酸被用作安全的交联剂。确定了均苯三甲酸对形成的薄膜的结构、机械、热和溶胀性能的影响。结果表明，添加均苯三甲酸可显著提高所获得材料的杨氏模量、拉伸强度和热稳定性。此外，应该强调的是，由壳聚糖和均苯三甲酸组成的样品的溶胀性高于纯壳聚糖。详细的表征证明，均苯三甲酸可用作新的有效交联剂。
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