• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从东乡野生稻（Griff.）内生真菌DX-THL3中分离得到的具有抗菌活性的新型蜂窝孢酸衍生物

New Helvolic Acid Derivatives with Antibacterial Activities from DX-THL3, an Endophytic Fungus from Dongxiang Wild Rice ( Griff.).

作者信息

Zhang Zhi-Bin, Du Si-Yao, Ji Bo, Ji Chang-Jiu, Xiao Yi-Wen, Yan Ri-Ming, Zhu Du

机构信息

Key Laboratory of Protection and Utilization of Subtropical Plant Resources of Jiangxi Province, College of Life Science, Jiangxi Normal University, Nanchang 330022, China.

College of Life Science, Jiangxi Science and Technology Normal University, Nanchang 330013, China.

出版信息

Molecules. 2021 Mar 24;26(7):1828. doi: 10.3390/molecules26071828.

DOI:10.3390/molecules26071828
PMID:33805102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8037696/
Abstract

Three new helvolic acid derivatives (named sarocladilactone A (), sarocladilactone B () and sarocladic acid A ()), together with five known compounds (6,16-diacetoxy-25-hy- droxy-3,7-dioxy-29-nordammara-1,17(20)-dien-21-oic acid (), helvolic acid (), helvolinic acid (), 6-desacetoxy-helvolic acid () and 1,2-dihydrohelvolic acid ()), were isolated from the endophytic fungus DX-THL3, obtained from the leaf of Dongxiang wild rice ( Griff.). The structures of the new compounds were elucidated via HR-MS, extensive 1D and 2D NMR analysis and comparison with reported data. Compounds , , , , and exhibited potent antibacterial activities. In particular, sarocladilactone B (), helvolinic acid () and 6-desacetoxy-helvolic acid () exhibited strongly inhibitory activity with minimum inhibitory concentration (MIC) values of 4, 1 and 4 μg/mL, respectively. The structure-activity relationship (SAR) of these compounds was primarily summarized.

摘要

从东乡野生稻（Griff.）叶片中分离得到的内生真菌DX - THL3中，分离出三种新的蠕孢酸衍生物（分别命名为帚枝霉内酯A（）、帚枝霉内酯B（）和帚枝霉酸A（）），以及五种已知化合物（6,16 - 二乙酰氧基 - 25 - 羟基 - 3,7 - 二氧基 - 29 - 降达玛烷 - 1,17(20) - 二烯 - 21 - 酸（）、蠕孢酸（）、蠕孢灵酸（）、6 - 去乙酰氧基蠕孢酸（）和1,2 - 二氢蠕孢酸（））。通过高分辨质谱、广泛的一维和二维核磁共振分析以及与已报道数据进行比较，阐明了新化合物的结构。化合物、、、、和表现出较强的抗菌活性。特别是，帚枝霉内酯B（）、蠕孢灵酸（）和6 - 去乙酰氧基蠕孢酸（）表现出强烈的抑制活性，其最低抑菌浓度（MIC）值分别为4、1和4 μg/mL。初步总结了这些化合物的构效关系（SAR）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/1bbb984606cd/molecules-26-01828-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/34b63fd57168/molecules-26-01828-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/e7816975219b/molecules-26-01828-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/1bbb984606cd/molecules-26-01828-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/34b63fd57168/molecules-26-01828-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/e7816975219b/molecules-26-01828-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6872/8037696/1bbb984606cd/molecules-26-01828-g003.jpg

相似文献

1
New Helvolic Acid Derivatives with Antibacterial Activities from DX-THL3, an Endophytic Fungus from Dongxiang Wild Rice ( Griff.).从东乡野生稻（Griff.）内生真菌DX-THL3中分离得到的具有抗菌活性的新型蜂窝孢酸衍生物
Molecules. 2021 Mar 24;26(7):1828. doi: 10.3390/molecules26071828.
2
A new helvolic acid derivative from an endophytic Fusarium sp. of Ficus carica.一种来自无花果内生镰刀菌的新型蜂窝酸衍生物。
Nat Prod Res. 2016 Nov;30(21):2407-12. doi: 10.1080/14786419.2016.1190722. Epub 2016 Jun 4.
3
De novo genome assembly and annotation of rice sheath rot fungus Sarocladium oryzae reveals genes involved in Helvolic acid and Cerulenin biosynthesis pathways.水稻鞘腐病菌稻梨孢的从头基因组组装与注释揭示了与蠕孢酸和浅蓝菌素生物合成途径相关的基因。
BMC Genomics. 2016 Mar 31;17:271. doi: 10.1186/s12864-016-2599-0.
4
Helvolic Acid Derivatives with Antibacterial Activities against Streptococcus agalactiae from the Marine-Derived Fungus Aspergillus fumigatus HNMF0047.海洋来源真菌烟曲霉 HNMF0047 中具有抗无乳链球菌活性的枝顶孢酸衍生物。
J Nat Prod. 2018 Aug 24;81(8):1869-1876. doi: 10.1021/acs.jnatprod.8b00382. Epub 2018 Aug 2.
5
Morphological, Pathogenic and Toxigenic Variability in the Rice Sheath Rot Pathogen .稻纹枯病菌的形态学、病理学和产毒变异性。
Toxins (Basel). 2020 Feb 8;12(2):109. doi: 10.3390/toxins12020109.
6
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis.土槿皮乙酸的生物合成及与甾醇生物合成不同的 C-4 去甲基化过程的鉴定。
Nat Commun. 2017 Nov 21;8(1):1644. doi: 10.1038/s41467-017-01813-9.
7
NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from .NF-κB 抑制和抗菌海洛因和黄曲霉素衍生物来自.
J Nat Prod. 2020 Mar 27;83(3):730-737. doi: 10.1021/acs.jnatprod.9b01190. Epub 2020 Mar 12.
8
Detection and quantification of phytotoxic metabolites of Sarocladium oryzae in sheath rot-infected grains of rice.水稻鞘腐病感染谷粒中稻梨孢植物毒性代谢产物的检测与定量分析
Lett Appl Microbiol. 2002;34(6):398-401. doi: 10.1046/j.1472-765x.2002.01111.x.
9
An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum.一种来自产黄顶孢霉的具有抗菌活性的夫西地酸类似物。
Phytochemistry. 2006 Oct;67(19):2110-4. doi: 10.1016/j.phytochem.2006.06.033. Epub 2006 Aug 22.
10
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus.致病真菌烟曲霉中原甾体烯醇的生物合成与代谢
Org Lett. 2009 Mar 19;11(6):1241-4. doi: 10.1021/ol802696a.

引用本文的文献

1
Emericellopsic acid, a helvolic acid derivative with a 6/5/7/5 tetracyclic skeleton from sponge-derived Emericellopsis maritima.埃默里西洛酸，一种来自海绵源海洋埃默里西洛菌的具有6/5/7/5四环骨架的蜂窝酸衍生物。
J Antibiot (Tokyo). 2025 Jul 29. doi: 10.1038/s41429-025-00852-5.
2
Antibacterial Compounds Isolated from Endophytic Fungi Reported from 2021 to 2024.2021年至2024年报道的从内生真菌中分离出的抗菌化合物
Antibiotics (Basel). 2025 Jun 25;14(7):644. doi: 10.3390/antibiotics14070644.
3
Preparation and evaluation of MSR-1 bioinoculant on the growth and productivity of (L.) R. Wilczek.

本文引用的文献

1
NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from .NF-κB 抑制和抗菌海洛因和黄曲霉素衍生物来自.
J Nat Prod. 2020 Mar 27;83(3):730-737. doi: 10.1021/acs.jnatprod.9b01190. Epub 2020 Mar 12.
2
Bioactive Secondary Metabolites from Endophytic Fungi.内生真菌中的生物活性次生代谢产物。
Curr Med Chem. 2020;27(11):1836-1854. doi: 10.2174/0929867326666190916144709.
3
Helvolic Acid Derivatives with Antibacterial Activities against Streptococcus agalactiae from the Marine-Derived Fungus Aspergillus fumigatus HNMF0047.
MSR-1生物肥料对（L.）R.威尔采克生长和生产力的制备与评价
3 Biotech. 2025 Feb;15(2):49. doi: 10.1007/s13205-025-04206-8. Epub 2025 Jan 21.
4
Endophytic Fungi from the Four Staple Crops and Their Secondary Metabolites.四粮作物内生真菌及其次生代谢产物。
Int J Mol Sci. 2024 May 31;25(11):6057. doi: 10.3390/ijms25116057.
5
Role of the Gene in Development, Secondary Metabolism and Virulence.该基因在发育、次生代谢和毒力中的作用。
J Fungi (Basel). 2024 Jan 26;10(2):103. doi: 10.3390/jof10020103.
6
(D.Don) D.Don ex Hook. & Arn.: A plant with medicinal value against inflammatory disorders and infections.（D. 唐）D. 唐 胡克 & 阿诺特：一种对炎症性疾病和感染具有药用价值的植物。
Heliyon. 2023 Apr 18;9(5):e15276. doi: 10.1016/j.heliyon.2023.e15276. eCollection 2023 May.
7
Screening for broad-spectrum antimicrobial endophytes from and multi-omic analyses of biosynthetic capacity.从[来源]中筛选广谱抗菌内生菌并对其生物合成能力进行多组学分析。 （你提供的原文“from and”这里似乎有缺失信息）
Front Plant Sci. 2022 Nov 16;13:1060478. doi: 10.3389/fpls.2022.1060478. eCollection 2022.
8
Endophytic Fungal Terpenoids: Natural Role and Bioactivities.内生真菌萜类化合物：天然作用与生物活性。
Microorganisms. 2022 Feb 1;10(2):339. doi: 10.3390/microorganisms10020339.
9
Fungal Endophytes: A Potential Source of Antibacterial Compounds.真菌内生菌：抗菌化合物的潜在来源。
J Fungi (Basel). 2022 Feb 8;8(2):164. doi: 10.3390/jof8020164.
海洋来源真菌烟曲霉 HNMF0047 中具有抗无乳链球菌活性的枝顶孢酸衍生物。
J Nat Prod. 2018 Aug 24;81(8):1869-1876. doi: 10.1021/acs.jnatprod.8b00382. Epub 2018 Aug 2.
4
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis.土槿皮乙酸的生物合成及与甾醇生物合成不同的 C-4 去甲基化过程的鉴定。
Nat Commun. 2017 Nov 21;8(1):1644. doi: 10.1038/s41467-017-01813-9.
5
Antimicrobial metabolites from the plant endophytic fungus Penicillium sp.植物内生真菌青霉属菌株产生的抗菌代谢产物
Fitoterapia. 2017 Jan;116:72-76. doi: 10.1016/j.fitote.2016.11.008. Epub 2016 Nov 19.
6
A new helvolic acid derivative from an endophytic Fusarium sp. of Ficus carica.一种来自无花果内生镰刀菌的新型蜂窝酸衍生物。
Nat Prod Res. 2016 Nov;30(21):2407-12. doi: 10.1080/14786419.2016.1190722. Epub 2016 Jun 4.
7
Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections.夫西地酸：一种用于口服治疗急慢性葡萄球菌感染的细菌延伸因子抑制剂。
Cold Spring Harb Perspect Med. 2016 Jan 4;6(1):a025437. doi: 10.1101/cshperspect.a025437.
8
Phylogenetic diversity of culturable endophytic fungi in Dongxiang wild rice (Oryza rufipogon Griff), detection of polyketide synthase gene and their antagonistic activity analysis.东乡野生稻（Oryza rufipogon Griff）中可培养内生真菌的系统发育多样性、聚酮合酶基因检测及其拮抗活性分析
Fungal Biol. 2015 Nov;119(11):1032-1045. doi: 10.1016/j.funbio.2015.07.009. Epub 2015 Aug 6.
9
Endophytes as in vitro production platforms of high value plant secondary metabolites.内生菌作为高价值植物次生代谢产物的体外生产平台。
Biotechnol Adv. 2015 Nov 1;33(6 Pt 1):873-87. doi: 10.1016/j.biotechadv.2015.07.004. Epub 2015 Jul 28.
10
New metabolites from the marine-derived fungus Aspergillus fumigatus.源自海洋的烟曲霉真菌产生的新代谢产物。
Nat Prod Commun. 2012 Apr;7(4):497-500.