Li Shasha, Hao Xiaomeng, Li Yan, Gan Maoluo
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China.
J Antibiot (Tokyo). 2025 Jul 29. doi: 10.1038/s41429-025-00852-5.
Emericellopsic acid (1), the first B/C ring-rearranged fusidane-type antibiotic possessing a 6/5/7/5-fused ring framework, together with seven known helvolic acid derivatives, was isolated from the sponge-associated fungus Emericellopsis maritima IMB18-123 cultivated with autoclaved Pseudomonas aeruginosa. The structure of 1 was determined by extensive spectroscopic data analysis combined with ECD calculation. Compound 1 exhibited moderate antimicrobial activities against Staphylococcus aureus and S. epidermidis with the minimum inhibition concentration of 4-8 μg ml.
埃默里西洛酸（1）是首个具有6/5/7/5稠环骨架的B/C环重排的夫西地烷型抗生素，与七种已知的蜂窝酸衍生物一起，是从用高压灭菌的铜绿假单胞菌培养的海绵相关真菌海生埃默里壳菌IMB18 - 123中分离得到的。通过广泛的光谱数据分析结合ECD计算确定了1的结构。化合物1对金黄色葡萄球菌和表皮葡萄球菌表现出中等抗菌活性，最低抑菌浓度为4 - 8μg/ml。
