Department of Nursing, Physiotherapy and Medicine, Health Research Center (CEINSA), University of Almeria, 04120 Almeria, Spain.
Department of Psychology, University of Almeria, 04120 Almeria, Spain.
Int J Environ Res Public Health. 2021 Mar 29;18(7):3543. doi: 10.3390/ijerph18073543.
Fibromyalgia syndrome (FMS) is a chronic, generalized and diffuse pain disorder accompanied by cognitive deficits such as forgetfulness, concentration difficulties, loss of vocabulary and mental slowness, among others. In recent years, FMS has been associated with altered intestinal microbiota, suggesting that modulating gut microbiota (for example, through probiotics) could be an effective therapeutic treatment. Thus, the aim of the present study was to continue exploring the role of probiotics in cognitive processes in patients with FMS. A pilot randomized controlled trial was conducted in 31 patients diagnosed with FMS to compare the effects of a multispecies probiotic versus a placebo on cognitive variables (memory and attention) after eight weeks. Results showed that treatment with a multispecies probiotic produced an improvement in attention by reducing errors on an attention task, but it had no effect on memory. More specifically, a tendency to reduce errors of omission (Go trials) during the Go/No-Go Task was observed after treatment. These findings, along with our previous results in impulsivity, underline the relevance of using probiotics as a therapeutic option in FMS, although more research with a larger sample size is required.
纤维肌痛综合征（FMS）是一种慢性、全身性、弥漫性疼痛障碍，伴有认知缺陷，如健忘、注意力困难、词汇丧失和思维迟钝等。近年来，FMS 与肠道微生物群的改变有关，这表明调节肠道微生物群（例如通过益生菌）可能是一种有效的治疗方法。因此，本研究旨在继续探索益生菌在 FMS 患者认知过程中的作用。一项针对 31 名 FMS 患者的随机对照试验表明，与安慰剂相比，使用多菌种益生菌 8 周后可改善注意力，减少注意力任务中的错误，但对记忆没有影响。具体而言，在 Go/No-Go 任务中，观察到在治疗后，错误遗漏（Go 试验）的趋势减少。这些发现，以及我们之前关于冲动性的结果，强调了使用益生菌作为 FMS 治疗选择的相关性，尽管需要更多的、更大样本量的研究。
