Faculty of Military Health Sciences, University of Defense, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic.
Biosensors (Basel). 2021 Mar 4;11(3):70. doi: 10.3390/bios11030070.
Glycated hemoglobin (HbA) is a product of the spontaneous reaction between hemoglobin and elevated glucose levels in the blood. It is included among the so-called advanced glycation end products, of which is the most important for the clinical diagnosis of diabetes mellitus, and it can serve as an alternative to glycemia measurement. Compared to the diagnosis of diabetes mellitus by glycemia, the HbA level is less influenced by a short-term problem with diabetes compensation. Mass spectroscopy and chromatographic techniques are among the standard methods of HbA level measurement. Compared to glycemia measurement, there is lack of simple methods for diabetes mellitus diagnosis by means of the HbA assay using a point-of-care test. This review article is focused on the surveying of facts about HbA and its importance in diabetes mellitus diagnosis, and surveying standard methods and new methods suitable for the HbA assay under point-of-care conditions. Various bioassays and biosensors are mentioned and their specifications are discussed.
糖化血红蛋白（HbA）是血红蛋白与血液中高血糖水平自发反应的产物。它属于所谓的晚期糖基化终产物，其中对糖尿病临床诊断最重要的是它可以作为血糖测量的替代方法。与血糖诊断糖尿病相比，HbA 水平受短期糖尿病补偿问题的影响较小。质谱和色谱技术是 HbA 水平测量的标准方法之一。与血糖测量相比，使用即时检验的 HbA 检测方法进行糖尿病诊断缺乏简单的方法。这篇综述文章重点介绍了 HbA 的调查结果及其在糖尿病诊断中的重要性，以及适合即时检验条件下的 HbA 检测的标准方法和新方法。文中提到了各种生物测定法和生物传感器，并讨论了它们的规格。
