Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India.
National Agri-Food Biotechnology Institute (NABI), Mohali, Punjab, India.
Int J Nanomedicine. 2021 Jan 14;16:383-402. doi: 10.2147/IJN.S267212. eCollection 2021.
Advancements in analytical diagnostic systems for point-of-care (POC) application have gained considerable attention because of their rapid operation at the site required to manage severe diseases, even in a personalized manner. The POC diagnostic devices offer easy operation, fast analytical outcome, and affordable cost, which promote their advanced research and versatile adoptability. Keeping advantages in view, considerable efforts are being made to design and develop smart sensing components such as miniaturized transduction, interdigitated electrodes-based sensing chips, selective detection at low level, portable packaging, and sustainable durability to promote POC diagnostics according to the needs of patient care. Such effective diagnostics systems are in demand, which creates the challenge to make them more efficient in every aspect to generate a desired bio-informatic needed for better health access and management. Keeping advantages and scope in view, this mini review focuses on practical scenarios associated with miniaturized analytical diagnostic devices at POC application for targeted disease diagnostics smartly and efficiently. Moreover, advancements in technologies, such as smartphone-based operation, paper-based sensing assays, and lab-on-a-chip (LOC) which made POC more sensitive, informative, and suitable for major infectious disease diagnosis, are the main focus here. Besides, POC diagnostics based on automated patient sample integration with a sensing platform is continuously improving therapeutics interventions against specific infectious disease. This review also discussed challenges associated with state-of-the-art technology along with future research opportunities to design and develop next generation POC diagnostic systems needed to manage infectious diseases in a personalized manner.
由于其在需要管理严重疾病的现场能够快速运作，即时是个性化管理，即时诊断系统在即时护理 (POC) 应用方面的进展也受到了相当大的关注。POC 诊断设备具有操作简单、分析结果快速和成本低廉的优点，这促进了它们的先进研究和多功能应用。鉴于这些优点，人们正在努力设计和开发智能感测元件，例如小型化换能器、基于叉指电极的感测芯片、低水平的选择性检测、便携式封装和可持续耐用性，以根据患者护理的需求促进 POC 诊断。对这种有效的诊断系统的需求很大，这就带来了挑战，需要使其在各个方面都更加高效，以产生所需的生物信息，从而改善健康的获取和管理。鉴于这些优点和范围，本迷你综述重点介绍了与 POC 应用中针对目标疾病的微型分析诊断设备相关的实际情况，以实现智能且高效的诊断。此外，这里的主要重点是基于智能手机操作、基于纸张的感测分析和芯片上实验室 (LOC) 的技术进步，这些技术使 POC 更敏感、更具信息性，并且更适合主要传染病的诊断。此外，基于与感测平台自动化整合患者样本的 POC 诊断正在不断改善针对特定传染病的治疗干预措施。本综述还讨论了与最先进技术相关的挑战，以及未来的研究机会，以设计和开发下一代 POC 诊断系统，从而以个性化的方式管理传染病。
