Haroutounian Arpie, Amorim Fabiano T, Astorino Todd A, Khodiguian Nazareth, Curtiss Katharine M, Matthews Aaron R D, Estrada Michael J, Fennel Zachary, McKenna Zachary, Nava Roberto, Sheard Ailish C
School of Kinesiology, Nutrition, and Food Science, California State University, Los Angeles, Los Angeles, CA 90032, USA.
Department of Health, Exercise, and Sports Sciences, University of New Mexico, Albuquerque, NM 87131, USA.
Nutrients. 2021 Mar 4;13(3):841. doi: 10.3390/nu13030841.
Implementing permissive dehydration (DEH) during short-term heat acclimation (HA) may accelerate adaptations to the heat. However, HA with DEH may augment risk for acute kidney injury (AKI). This study investigated the effect of HA with permissive DEH on time-trial performance and markers of AKI. Fourteen moderately trained men (age and VO = 25 ± 0.5 yr and 51.6 ± 1.8 mLkgmin) were randomly assigned to DEH or euhydration (EUH). Time-trial performance and VO were assessed in a temperate environment before and after 7 d of HA. Heat acclimation consisted of 90 min of cycling in an environmental chamber (40 °C, 35% RH). Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) were assessed pre- and post-exercise on day 1 and day 7 of HA. Following HA, VO did not change in either group ( = 0.099); however, time-trial performance significantly improved (3%, < 0.01) with no difference between groups ( = 0.485). Compared to pre-exercise, NGAL was not significantly different following day 1 and 7 of HA ( = 0.113) with no difference between groups ( = 0.667). There was a significant increase in KIM-1 following day 1 and 7 of HA ( = 0.002) with no difference between groups ( = 0.307). Heat acclimation paired with permissive DEH does not amplify improvements in VO or time-trial performance in a temperate environment versus EUH and does not increase markers of AKI.
在短期热适应（HA）过程中实施允许性脱水（DEH）可能会加速对热的适应。然而，HA合并DEH可能会增加急性肾损伤（AKI）的风险。本研究调查了HA合并允许性DEH对计时赛成绩和AKI标志物的影响。14名中度训练的男性（年龄和VO₂ = 25 ± 0.5岁，51.6 ± 1.8 mL·kg⁻¹·min⁻¹）被随机分配至DEH组或正常水合（EUH）组。在HA 7天前后，于温带环境中评估计时赛成绩和VO₂。热适应包括在环境舱（40℃，35%相对湿度）中进行90分钟的骑行。在HA第1天和第7天运动前后评估中性粒细胞明胶酶相关脂质运载蛋白（NGAL）和肾损伤分子-1（KIM-1）。HA后，两组的VO₂均未改变（P = 0.099）；然而，计时赛成绩显著提高（3%，P < 0.01），两组间无差异（P = 0.485）。与运动前相比，HA第1天和第7天后NGAL无显著差异（P = 0.113），两组间无差异（P = 0.667）。HA第1天和第7天后KIM-1显著增加（P = 0.002），两组间无差异（P = 0.307）。与EUH相比，在温带环境中，HA合并允许性DEH不会增强VO₂或计时赛成绩的改善，也不会增加AKI的标志物。
