Lee Dongun, Hong Jeong Hee
Department of Health Sciences and Technology, Lee Gil Ya Cancer and Diabetes Institute, GAIHST, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Korea.
Cancers (Basel). 2021 Mar 23;13(6):1473. doi: 10.3390/cancers13061473.
Metastatic features of breast cancer in the brain are considered a common pathology in female patients with late-stage breast cancer. Ca signaling and the overexpression pattern of Ca channels have been regarded as oncogenic markers of breast cancer. In other words, breast tumor development can be mediated by inhibiting Ca channels. Although the therapeutic potential of inhibiting Ca channels against breast cancer has been demonstrated, the relationship between breast cancer metastasis and Ca channels is not yet understood. Thus, we focused on the metastatic features of breast cancer and summarized the basic mechanisms of Ca-related proteins and channels during the stages of metastatic breast cancer by evaluating Ca signaling. In particular, we highlighted the metastasis of breast tumors to the brain. Thus, modulating Ca channels with Ca channel inhibitors and combined applications will advance treatment strategies for breast cancer metastasis to the brain.
乳腺癌脑转移特征被认为是晚期乳腺癌女性患者的常见病理情况。钙信号传导及钙通道的过表达模式已被视为乳腺癌的致癌标志物。换句话说，乳腺肿瘤的发展可通过抑制钙通道来介导。尽管抑制钙通道对乳腺癌的治疗潜力已得到证实，但乳腺癌转移与钙通道之间的关系尚不清楚。因此，我们聚焦于乳腺癌的转移特征，并通过评估钙信号传导总结了转移性乳腺癌各阶段钙相关蛋白和通道的基本机制。特别是，我们着重探讨了乳腺肿瘤向脑的转移。因此，使用钙通道抑制剂调节钙通道以及联合应用将推动针对乳腺癌脑转移的治疗策略。
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