环状 RNA-蛋白质相互作用在肌肉发育和疾病中的作用。
CircRNA-Protein Interactions in Muscle Development and Diseases.
机构信息
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
出版信息
Int J Mol Sci. 2021 Mar 23;22(6):3262. doi: 10.3390/ijms22063262.
Circular RNA (circRNA) is a kind of novel endogenous noncoding RNA formed through back-splicing of mRNA precursor. The biogenesis, degradation, nucleus-cytoplasm transport, location, and even translation of circRNA are controlled by RNA-binding proteins (RBPs). Therefore, circRNAs and the chaperoned RBPs play critical roles in biological functions that significantly contribute to normal animal development and disease. In this review, we systematically characterize the possible molecular mechanism of circRNA-protein interactions, summarize the latest research on circRNA-protein interactions in muscle development and myocardial disease, and discuss the future application of circRNA in treating muscle diseases. Finally, we provide several valid prediction methods and experimental verification approaches. Our review reveals the significance of circRNAs and their protein chaperones and provides a reference for further study in this field.
环状 RNA（circRNA）是一种通过 mRNA 前体的反向剪接形成的新型内源性非编码 RNA。circRNA 的生物发生、降解、核质转运、定位甚至翻译都受到 RNA 结合蛋白（RBPs）的控制。因此，circRNA 和被其伴侣的 RBPs 在生物学功能中发挥着关键作用，这些功能对正常动物的发育和疾病有重要贡献。在这篇综述中，我们系统地描述了 circRNA-蛋白相互作用的可能分子机制，总结了最近关于 circRNA-蛋白相互作用在肌肉发育和心肌疾病中的研究，并讨论了 circRNA 在治疗肌肉疾病中的未来应用。最后，我们提供了几种有效的预测方法和实验验证方法。我们的综述揭示了 circRNAs 及其蛋白伴侣的重要性，为该领域的进一步研究提供了参考。
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