Lytkina Daria N, Fedorishin Dmitriy A, Kalachikova Polina M, Plyaskina Anastasiya A, Babeshin Aleksandr R, Kurzina Irina A
Chemical Department, National Research Tomsk State University, Lenin 36, 634050 Tomsk, Russia.
Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, bld. 1, 121205 Moscow, Russia.
J Funct Biomater. 2021 Mar 5;12(1):18. doi: 10.3390/jfb12010018.
The application of various materials in biomedical procedures has recently experienced rapid growth. One of the areas is the treatment of many of different types of bone-related diseases and disorders by using biodegradable polymer-ceramic composites. We have developed a material based on cryogel polyvinyl alcohol, mineralized with calcium phosphate. Composites were obtained by cyclic freezing-thawing, the synthesis of calcium phosphates was carried out in situ under the influence of microwave radiation with heating and stirring. The components of the composites were determined using the methods of IR-spectroscopy and scanning electron microscopy and electron probe microanalyzer, as well as their morphology and surface properties. The biological compatibility of the material was investigated in vivo for a Wistar rat. The assessment of the quality of bone formation between the cryogel-based implant and the damaged bone was carried out by computed tomography. An improvement in the consolidation of the bone defect is observed in the bone with the composite in comparison with the control bone.
各种材料在生物医学程序中的应用近年来发展迅速。其中一个领域是通过使用可生物降解的聚合物-陶瓷复合材料来治疗多种不同类型的骨相关疾病和病症。我们开发了一种基于冷冻凝胶聚乙烯醇并经磷酸钙矿化的材料。通过循环冻融获得复合材料，磷酸钙的合成在微波辐射加热和搅拌的影响下原位进行。使用红外光谱、扫描电子显微镜和电子探针微分析仪等方法确定了复合材料的成分及其形态和表面性质。在Wistar大鼠体内研究了该材料的生物相容性。通过计算机断层扫描对基于冷冻凝胶的植入物与受损骨之间的骨形成质量进行评估。与对照骨相比，含有复合材料的骨中骨缺损的愈合情况有所改善。
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