But-Hadzic Jasna, Dervisevic Mirza, Karpljuk Damir, Videmsek Mateja, Dervisevic Edvin, Paravlic Armin, Hadzic Vedran, Tomazin Katja
Department of Radiation Oncology, Institute of Oncology, 1000 Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Int J Environ Res Public Health. 2021 Mar 5;18(5):2591. doi: 10.3390/ijerph18052591.
The six-minute walk test (6MWT) is a widely used test for the indirect measurement of cardiorespiratory fitness in various cancer populations. Although the 6MWT is a simple test, there are no normative values for breast cancer survivors (BCS) or comparisons of results with healthy counterparts. A systematic review with a meta-analysis was carried out, which included studies from 2007 to 2020. Ninety-one studies were found, 21 of which were included in the quantitative synthesis. Among them were 9 randomized controlled trials (RCT), 8 prospective cohort studies and 4 cross-sectional studies. A total of 1084 BCS were included. Our results revealed that healthy subjects (n = 878) covered a significantly greater distance than BCS during the 6MWT (589.9 m vs. 477.4 m, < 0.001), and the results of the meta-regression analysis showed that the 6MWD was predicted by the participants' BMI ( < 0.001), but not by their age ( = 0.070). After adjustment for BMI, the healthy subjects also covered greater distances than the BCS (103 m; < 0.001). The normative values of 6MWT were presented for BCS. Besides, 6MWT distances distinguish between their healthy counterparts, therefore, the 6MWT distance is a relevant parameter for the assessment and monitoring of cardiorespiratory fitness in medical and exercise interventions for BCS.
六分钟步行试验（6MWT）是一种广泛用于间接测量各类癌症患者心肺适能的测试。尽管6MWT是一项简单的测试，但目前尚无乳腺癌幸存者（BCS）的标准值，也没有与健康对照者的结果比较。我们进行了一项系统评价并荟萃分析，纳入了2007年至2020年的研究。共检索到91项研究，其中21项纳入定量合成。其中包括9项随机对照试验（RCT）、8项前瞻性队列研究和4项横断面研究。总共纳入了1084例BCS。我们的结果显示，在6MWT期间，健康受试者（n = 878）行走的距离明显长于BCS（589.9米对477.4米，<0.001），荟萃回归分析结果表明，6MWD可由参与者的BMI预测（<0.001），但不能由年龄预测（=0.070）。在对BMI进行调整后，健康受试者行走的距离仍长于BCS（103米；<0.001）。给出了BCS的6MWT标准值。此外，6MWT行走距离可区分健康对照者，因此，6MWT行走距离是评估和监测BCS医疗和运动干预中心肺适能的一个相关参数。
