Folliero Veronica, Zannella Carla, Chianese Annalisa, Stelitano Debora, Ambrosino Annalisa, De Filippis Anna, Galdiero Marilena, Franci Gianluigi, Galdiero Massimiliano
Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Department of Pharmacy, University of Naples "Federico II", 80131 Naples, Italy.
Pharmaceutics. 2021 Mar 5;13(3):343. doi: 10.3390/pharmaceutics13030343.
Despite advances in medical knowledge, parasitic diseases remain a significant global health burden and their pharmacological treatment is often hampered by drug toxicity. Therefore, drug delivery systems may provide useful advantages when used in combination with conventional therapeutic compounds. Dendrimers are three-dimensional polymeric structures, characterized by a central core, branches and terminal functional groups. These nanostructures are known for their defined structure, great water solubility, biocompatibility and high encapsulation ability against a wide range of molecules. Furthermore, the high ratio between terminal groups and molecular volume render them a hopeful vector for drug delivery. These nanostructures offer several advantages compared to conventional drugs for the treatment of parasitic infection. Dendrimers deliver drugs to target sites with reduced dosage, solving side effects that occur with accepted marketed drugs. In recent years, extensive progress has been made towards the use of dendrimers for therapeutic, prophylactic and diagnostic purposes for the management of parasitic infections. The present review highlights the potential of several dendrimers in the management of parasitic diseases.
尽管医学知识不断进步，但寄生虫病仍然是全球重大的健康负担，其药物治疗常常受到药物毒性的阻碍。因此，药物递送系统与传统治疗化合物联合使用时可能会带来有益的优势。树枝状大分子是三维聚合物结构，其特征在于有一个中心核、分支和末端官能团。这些纳米结构以其明确的结构、良好的水溶性、生物相容性以及对多种分子的高包封能力而闻名。此外，末端基团与分子体积之间的高比例使它们成为药物递送的有希望的载体。与用于治疗寄生虫感染的传统药物相比，这些纳米结构具有几个优点。树枝状大分子以降低的剂量将药物递送至靶位点，解决了市售药物所出现的副作用。近年来，在将树枝状大分子用于寄生虫感染管理的治疗、预防和诊断目的方面已经取得了广泛的进展。本综述强调了几种树枝状大分子在寄生虫病管理中的潜力。
