Razanamahery Jerome, Bouldoires Bastien, Humbert Sebastien, Bielefeld Philip, Fournier Veronique, Bonnotte Bernard, Blaison Gilles, Magy-Bertrand Nadine
Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, 21000 Dijon, France.
Department of Internal Medicine, Hopital Pasteur, 68000 Colmar, France.
J Clin Med. 2021 Mar 30;10(7):1380. doi: 10.3390/jcm10071380.
To compare adult patients' characteristics suffering from idiopathic retroperitoneal fibrosis between "relapse-free" and relapsing patients at the diagnosis and identify factors associated with relapse at initial presentation.
We conducted a retrospective multicentric study in four hospitals in Eastern France, from 1993 to 2020, of adult patients suffering from idiopathic retroperitoneal fibrosis. We analyzed clinical, biological, and radiological features at diagnosis and during a forty-month follow-up.
Of 47 patients suffering from retroperitoneal fibrosis, 21 patients had idiopathic retroperitoneal fibrosis. Among them, 13 experienced one or more relapses during follow-up. At diagnosis, clinical characteristics, relevant comorbidities, biological and radiological features were similar between groups. Smoking cessation seems associated with decreased relapse risk (: 0.0624). A total of 8 patients developed chronic renal failure during follow-up. Ureteral infiltration at diagnosis was associated with evolution to chronic renal failure (: 0.0091).
No clinical, biological, or radiological features could predict relapse at retroperitoneal fibrosis diagnosis, but smoking cessation may prevent relapse.
比较“无复发”和复发的特发性腹膜后纤维化成年患者在诊断时的特征，并确定初始表现时与复发相关的因素。
我们于1993年至2020年在法国东部的四家医院进行了一项回顾性多中心研究，研究对象为患有特发性腹膜后纤维化的成年患者。我们分析了诊断时以及40个月随访期间的临床、生物学和放射学特征。
在47例腹膜后纤维化患者中，21例患有特发性腹膜后纤维化。其中，13例在随访期间经历了一次或多次复发。诊断时，两组间的临床特征、相关合并症、生物学和放射学特征相似。戒烟似乎与复发风险降低相关（：0.0624）。共有8例患者在随访期间出现慢性肾衰竭。诊断时输尿管受累与发展为慢性肾衰竭相关（：0.0091）。
在腹膜后纤维化诊断时，没有临床、生物学或放射学特征能够预测复发，但戒烟可能预防复发。
