Kaliszewska Aleksandra, Allison Joseph, Martini Matteo, Arias Natalia
Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, London SE5 8AF, UK.
Department of Psychology, University of East London, London E154LZ, UK.
Int J Mol Sci. 2021 Mar 30;22(7):3574. doi: 10.3390/ijms22073574.
Aging is inevitable and it is one of the major contributors to cognitive decline. However, the mechanisms underlying age-related cognitive decline are still the object of extensive research. At the biological level, it is unknown how the aging brain is subjected to progressive oxidative stress and neuroinflammation which determine, among others, mitochondrial dysfunction. The link between mitochondrial dysfunction and cognitive impairment is becoming ever more clear by the presence of significant neurological disturbances in human mitochondrial diseases. Possibly, the most important lifestyle factor determining mitochondrial functioning is nutrition. Therefore, with the present work, we review the latest findings disclosing a link between nutrition, mitochondrial functioning and cognition, and pave new ways to counteract cognitive decline in late adulthood through diet.
衰老不可避免，且是认知能力下降的主要因素之一。然而，与年龄相关的认知能力下降背后的机制仍是广泛研究的对象。在生物学层面，衰老的大脑如何遭受渐进性氧化应激和神经炎症尚不清楚，而这些因素尤其会导致线粒体功能障碍。人类线粒体疾病中存在明显的神经功能紊乱，这使得线粒体功能障碍与认知障碍之间的联系日益清晰。可能决定线粒体功能的最重要生活方式因素是营养。因此，在本研究中，我们回顾了揭示营养、线粒体功能与认知之间联系的最新发现，并为通过饮食对抗成年后期认知能力下降开辟新途径。
