Mikulska Aniceta Ada, Grzelak Teresa, Pelczyńska Marta, Bogdański Paweł, Czyżewska Krystyna
Chair and Department of Physical Pharmacy and Pharmacokinetics, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland.
Chair and Department of Physiology, Poznan University of Medical Sciences, 6 Święcickiego Street, 60-781 Poznań, Poland.
Biomolecules. 2021 Mar 30;11(4):517. doi: 10.3390/biom11040517.
Circadian rhythms misalignment is associated with hypertension. The aim of the study was to evaluate the concentration of selected clock proteins-cryptochrome 1 (CRY1) and circadian locomotor output cycles kaput (CLOCK) to determine their relationships with biochemical and anthropometric parameters and lifestyle elements (diet, physical activity, and quality of sleep) in hypertensive patients.
In 31 females with hypertension (HT) and 55 non-hypertensive women (NHT) the CRY1 and CLOCK concentrations, total antioxidant status (TAS), lipid profile, and glycemia were analyzed. Blood pressure and anthropometric measurements, nutritional, exercise, and sleep analyses were performed.
In the HT group, the CRY1 level was 37.38% lower than in the NHT group. No differences were noted in CLOCK concentration between groups. BMI, FBG, and TG were higher in the HT group compared to the NHT group, while TC, LDL, and HDL levels were similar. The study showed no relationship between CRY1 or CLOCK concentrations and glucose or lipids profile, amount of physical activity, or sleep quality, although CRY1 was associated with some anthropometric indicators. In the HT group, increased CLOCK and CRY1 values were associated with a high TAS level.
The serum level of CRY1 could be considered in a detailed diagnostic of hypertension risk in populations with abnormal anthropometric indices.
昼夜节律失调与高血压有关。本研究的目的是评估特定生物钟蛋白——隐花色素1（CRY1）和昼夜运动输出周期蛋白（CLOCK）的浓度，以确定它们与高血压患者生化和人体测量参数以及生活方式因素（饮食、体育活动和睡眠质量）之间的关系。
分析了31名高血压女性患者（HT）和55名非高血压女性（NHT）的CRY1和CLOCK浓度、总抗氧化状态（TAS）、血脂谱和血糖水平。进行了血压和人体测量、营养、运动及睡眠分析。
HT组的CRY1水平比NHT组低37.38%。两组间CLOCK浓度无差异。HT组的BMI、空腹血糖（FBG）和甘油三酯（TG）高于NHT组，而总胆固醇（TC）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）水平相似。研究表明，CRY1或CLOCK浓度与血糖或血脂谱、体育活动量或睡眠质量之间无关联，尽管CRY1与一些人体测量指标有关。在HT组中，CLOCK和CRY1值升高与高TAS水平相关。
在人体测量指标异常的人群中，CRY1的血清水平可用于高血压风险的详细诊断。
