Škrlec Ivana, Talapko Jasminka, Juzbašić Martina, Steiner Robert
Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, HR-31000 Osijek, Croatia.
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Josipa Huttlera 4, HR-31000 Osijek, Croatia.
J Cardiovasc Dev Dis. 2021 May 8;8(5):53. doi: 10.3390/jcdd8050053.
The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy-chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes , , and in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the , , and genes were analyzed. The Chi-square test yielded statistically significant differences in gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes , , and did not significantly differ between the sexes. According to the study's current results, the gene's genetic variability might affect myocardial infarction concerning biological sex.
越来越多的证据表明，基于生物性别，心血管疾病的昼夜节律存在显著差异。心血管疾病的发病率在女性和男性之间有所不同。此外，生物性别对于及时应用治疗方法——时间疗法至关重要，该疗法对两性均有益。本研究旨在探讨心肌梗死女性和男性中昼夜节律基因、、和的单核苷酸多态性（SNP）的潜在差异。进行了一项横断面研究，纳入200例心肌梗死患者。总共分析了、、和基因中的10个单核苷酸多态性。卡方检验显示，在隐性基因型模型中，基因rs11932595多态性在心肌梗死女性和男性之间存在统计学显著差异，p值为0.03，比值比为2.66，相应的95%置信区间为1.07至6.66。昼夜节律基因、和的其他分析多态性在两性之间没有显著差异。根据该研究的当前结果，基因的遗传变异性可能在生物性别方面影响心肌梗死。
