Systematic Analysis of Combined Antioxidant and Membrane-Stabilizing Properties of Several Family Kazakhstani Plants for Potential Production of Tea Beverages.

One of the most important compounds that exhibit a wide range of biological activities with especially strong antioxidant action are plant polyphenols. In the course of the experiment, the dose-dependent effects of polyphenols-rich extracts isolated from the family Kazakhstani plants were studied on the processes of lipid peroxidation and on the degree of erythrocytes hemolysis. The activity of aqueous-ethanolic extracts from dried parts of plants, such as , , , , , , and , was studied in a Wistar rat model. Lipid peroxidation (LPO) in liver microsomes was assessed by measuring malondialdehyde content in the form of thiobarbituric acid-reacting substances (TBARS). Estimation of osmotic resistance of isolated erythrocytes was evaluated based on hemoglobin absorbance. The amount of total phenolics in the extracts was measured using the Folin-Ciocalteu reagent method. Based on the results, extract exhibited a significantly higher antioxidant activity (IC50 = 3.3 ± 0.7) compared to other plant extracts. Accordingly, among the extracts studied, those from , , and show the most pronounced membrane-stabilizing activity. Antioxidant and antihemolytic properties of green tea and extract mixtures were similar to that of each individual plant extract. Similar results were obtained when the green tea extract was mixed with , , and extracts, indicating no discernible synergistic interaction.