Oh Hong Gi, Jeon Dong Cheol, Gianti Mahmudah Salwa, Cho Hae Shin, Jo Da Ae, Indriatmoko Muhammad Naufal, Jang Byoung Kuk, Lim Joon Mook, Cho Seungmin, Song Kwang Soup
Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, Gumi 39177, Korea.
Department of Internal Medicine, Keimyung University School of Medicine, Daegu 41931, Korea.
Nanomaterials (Basel). 2021 Mar 19;11(3):787. doi: 10.3390/nano11030787.
The monitoring of Na ions distributed in the body has been indirectly calculated by the detection of Na ions in urine. We fabricated a two-dimensional (2D) Na ion sensor using a graphene ion-sensitive field-effect transistor (G-ISFET) and used fluorinated graphene as a reference electrode (FG-RE). We integrated G-ISFET and FG on a printed circuit board (PCB) designed in the form of a secure digital (SD) card to fabricate a disposable Na ion sensor. The sensitivity of the PCB tip to Na ions was determined to be -55.4 mV/dec. The sensor exhibited good linearity despite the presence of interfering ions in the buffer solution. We expanded the evaluation of the PCB tip to real human patient urine samples. The PCB tip exhibited a sensitivity of -0.36 mV/mM and linearly detected Na ions in human patient urine without any dilution process. We expect that G-ISFET with FG-RE can be used to realize a disposable Na ion sensor by serving as an alternative to Ag/AgCl reference electrodes.
通过检测尿液中的钠离子来间接计算体内分布的钠离子含量。我们使用石墨烯离子敏感场效应晶体管（G-ISFET）制作了二维（2D）钠离子传感器，并将氟化石墨烯用作参考电极（FG-RE）。我们将G-ISFET和FG集成在以安全数字（SD）卡形式设计的印刷电路板（PCB）上，以制造一次性钠离子传感器。确定该PCB尖端对钠离子的灵敏度为-55.4 mV/dec。尽管缓冲溶液中存在干扰离子，该传感器仍表现出良好的线性。我们将对PCB尖端的评估扩展到实际人类患者的尿液样本。该PCB尖端表现出-0.36 mV/mM的灵敏度，并且无需任何稀释过程即可线性检测人类患者尿液中的钠离子。我们期望带有FG-RE的G-ISFET可以替代Ag/AgCl参考电极，用于实现一次性钠离子传感器。
