Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
Molecules. 2021 Mar 22;26(6):1769. doi: 10.3390/molecules26061769.
The discovery of various sartans, which are among the most used antihypertensive drugs in the world, is increasingly frequent not only in wastewater but also in surface water and, in some cases, even in drinking or groundwater. In this paper, the degradation pathway of olmesartan acid, one of the most used sartans, was investigated by simulating the chlorination process normally used in a wastewater treatment plant to reduce similar emerging pollutants. The structures of nine isolated degradation byproducts (DPs), eight of which were isolated for the first time, were separated via chromatography column and HPLC methods, identified by combining nuclear magnetic resonance and mass spectrometry, and justified by a proposed mechanism of formation beginning from the parent drug. Ecotoxicity tests on olmesartan acid and its nine DPs showed that 50% of the investigated byproducts inhibited the target species and , causing functional decreases of 18% and 53%, respectively.
各种沙坦类药物（sartans）的发现越来越频繁，这些药物是世界上使用最广泛的降压药之一，不仅在废水中，而且在地表水，甚至在某些情况下，甚至在饮用水和地下水中都有发现。在本文中，通过模拟通常用于废水处理厂的氯化过程来研究奥美沙坦酸（olmesartan acid，一种使用最广泛的沙坦类药物之一）的降解途径，以减少类似的新兴污染物。通过色谱柱和 HPLC 方法分离了 9 种分离出的降解副产物（DPs），其中 8 种是首次分离得到的，通过结合核磁共振和质谱鉴定了它们的结构，并通过从母体药物开始的形成机制进行了验证。对奥美沙坦酸及其 9 种 DPs 的生态毒性测试表明，在所研究的副产物中有 50%抑制了目标物种 和 ，分别导致功能下降 18%和 53%。
