Department of Chemical Sciences, University of Naples Federico II, Via Vicinale Cupa Cintia 26, 80126 Naples, Italy.
Department of Biology, University of Naples Federico II, Via Vicinale Cupa Cintia 26, 80126 Naples, Italy.
Molecules. 2022 Aug 19;27(16):5286. doi: 10.3390/molecules27165286.
Octocrylene is an organic sunscreen whose main action is to absorb UVB radiation and short UVA wavelengths; it is used in various cosmetic products in order to provide an adequate sun-protection factor or to protect the cosmetic formulations themselves from UV radiation. This filter is believed to be a possible endocrine disruptor and is also questioned due to its allergic and/or photoallergic potential. However, it continues to be widely used, and it has been found in various environments, not least those of swimming pools, where it is evidently released by consumers, to the point that it is now considered an emerging micropollutant. The present investigation presents the possible chemical fate of octocrylene in the typical chlorination conditions of wastewater or swimming pools. A total of 11 disinfection byproducts were identified, and 6 were identified for the first time, and separated by HPLC. These products were identified through careful mass spectrometry studies and 1D and 2D NMR experiments. A formation mechanism has been proposed that justifies the chemical structures of all of the compounds identified. The ecotoxicological assessment of octocrylene and their products was carried out by employing , and as bioindicators. The ecotoxicity results reveal that toxic byproducts might be generated during the oxidation process, increasing the potential risk to the marine environment.
辛氧烷醇是一种有机防晒霜，其主要作用是吸收 UVB 辐射和短 UVA 波长；它被用于各种化妆品产品中，以提供足够的防晒因子或保护化妆品配方本身免受 UV 辐射。这种滤光剂被认为是一种潜在的内分泌干扰物，也因其过敏和/或光过敏的潜在可能性而受到质疑。然而，它仍在广泛使用，并在各种环境中被发现，尤其是游泳池中，消费者显然会将其释放出来，以至于它现在被认为是一种新兴的微污染物。本研究提出了辛氧烷醇在废水或游泳池典型氯化条件下的可能化学命运。总共鉴定出 11 种消毒副产物，其中 6 种是首次鉴定，并通过 HPLC 分离。这些产物是通过仔细的质谱研究和 1D 和 2D NMR 实验鉴定的。提出了一个形成机制，该机制证明了所有鉴定化合物的化学结构的合理性。采用 、 和 作为生物标志物，对辛氧烷醇及其产物进行了生态毒理学评估。生态毒理学结果表明，氧化过程中可能会产生有毒副产物，从而增加对海洋环境的潜在风险。
