Tudoran Mariana, Tudoran Cristina, Lazureanu Voichita Elena, Marinescu Adelina Raluca, Pop Gheorghe Nicusor, Pescariu Alexandru Silvius, Enache Alexandra, Cut Talida Georgiana
Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041, Timisoara, Romania.
J Pers Med. 2021 Mar 22;11(3):225. doi: 10.3390/jpm11030225.
(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6-10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance.
（1）背景：冠状病毒感染（新冠病毒病-19）已成为一种严重的病症，伴有高肺部发病率，且常伴有心血管并发症。本研究旨在通过经胸超声心动图（TTE）证明无心血管疾病史的新冠病毒病-19患者左心室（LV）收缩功能（LV-SF）改变和舒张功能障碍（DD）的持续性。（2）方法：125例年龄在55岁以下、在新冠病毒病-19首次爆发期间因中度肺炎住院的患者，在出院后6至10周接受了全面的心脏检查和TTE。他们的初始住院实验室数据和胸部计算机断层扫描（TCT）从医院的电子数据库中获取。（3）结果：通过TTE，我们记录到8.8%的患者存在LV-SF改变和DD，仅16.8%的患者存在DD模式，与肌酸激酶（CK-MB）和炎症因子的初始水平具有统计学相关性。多变量回归分析表明，CK-MB水平、年龄和体重指数（BMI）导致了65%的LV-SF下降。（4）结论：急性新冠病毒病-19感染后，LV-SF改变和DD很常见，并导致症状持续。急性期心肌坏死标志物升高似乎可预测随后的心脏功能改变。
