Istratov Vladislav V, Vasnev Valerii A, Markova Galy D
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russia.
Molecules. 2021 Mar 26;26(7):1893. doi: 10.3390/molecules26071893.
In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules' molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.
在本研究中，通过用有机硅取代基修饰支化聚醚和聚酯的外围羟基，获得了新型可生物降解且具有生物相容性的两亲聚合物。合成聚合物的结构通过核磁共振（NMR）和凝胶渗透色谱（GPC）得以确认。聚合物的有机硅部分由硅氮烷和三甲基硅基嵌段形成，分别表现出亲水性和疏水性。研究了亲水性与疏水性有机硅结构的比例对大分子表面活性和生物活性的影响，以及大分子分子量和化学结构对这些活性的影响。特别地，测定了临界胶束浓度，描述了聚合物结构对其在玻璃和石蜡膜上被水溶液润湿的影响，并研究了乳液的聚集稳定性。最后，考察了聚合物结构对其抗真菌活性和种子萌发刺激作用的影响。
