Tille Eric, Beyer Franziska, Auerbach Kai, Tinius Marco, Lützner Jörg
University Center for Orthopaedic, Trauma- and Plastic Surgery, University Medicine Carl Gustav Carus Dresden, Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Arthromed Praxisklinik Chemnitz, Chemnitz, Germany.
BMC Musculoskelet Disord. 2021 Apr 2;22(1):326. doi: 10.1186/s12891-021-04185-w.
Unicompartmental knee arthroplasty (UKA) is an established treatment option for patients with unicompartmental osteoarthritis (OA). However, strict patient selection is crucial for its success. The proposed advantages include nearly natural knee kinematics, faster rehabilitation and better functional outcomes. Despite the aforementioned facts and it's proven cost-effectiveness, there are still hesitations for the use of UKA as an alternative to total knee arthroplasty (TKA). Key objectives of this study were therefore to assess clinical and patient-reported outcome (PRO) as well as patient's satisfaction after medial UKA in comparison to TKA.
To assess the outcome after UKA we conducted a prospective multi-center study. 116 patients with unicompartmental OA and indication for UKA were included. Overall 54 females and 62 males with an average age of 62.7 years (±9.8) and an average body mass index (BMI) of 29.2 (± 3.7) were recruited. Clinical results and PRO were assessed using the Knee Society Score (KSS). Follow-ups took place 3 months, 1 and 2 years after surgery including clinical examination, radiographs, assessment of PRO and adverse events. Pain and satisfaction was evaluated using a visual analog scale (VAS, 0 (worst) to 10 (best)). For comparison with TKA a propensity score matched-pair analysis was performed to eliminate confounders. Matching criteria were gender, patient's age, BMI and comorbidities. A total of 116 matched-pairs were analysed.
There was no revision in the UKA group until 2 years after surgery. Revision rates were higher in the TKA group (0.6%). Preoperative KSS-Scores were higher within the UKA cohort (p < 0.001). After surgical treatment, PROMs displayed a significant improvement (p < 0,001) in both cohorts. Regarding the Knee-Score (Pain, Alignment, ROM) we observed no differences between cohorts after 12 months. The Function-Score demonstrated significantly better results in the UKA cohort (UKA vs. TKA 95 vs 80, p < 0.001). Patient satisfaction was also higher in UKA patients (UKA vs TKA 9.0 vs 8.8, p = 0.019).
Patients of both cohorts showed high satisfaction after knee arthroplasty. UKA resulted in higher function scores compared to TKA without increased revision rate during short-term follow-up. Therefore, UKA is a good treatment option for unicompartmental OA.
Clinicaltrials.gov, NCT04598568 . Registered 22 October 2020 - Retrospectively registered.
单髁膝关节置换术(UKA)是治疗单髁骨关节炎(OA)患者的一种既定治疗选择。然而,严格的患者选择对其成功至关重要。其潜在优势包括近乎自然的膝关节运动学、更快的康复和更好的功能结果。尽管有上述事实且已证实其成本效益,但对于将UKA用作全膝关节置换术(TKA)的替代方案仍存在犹豫。因此,本研究的主要目的是评估内侧UKA与TKA相比的临床和患者报告结局(PRO)以及患者满意度。
为评估UKA术后结局,我们进行了一项前瞻性多中心研究。纳入了116名单髁OA且有UKA指征的患者。共招募了54名女性和62名男性,平均年龄62.7岁(±9.8),平均体重指数(BMI)为29.2(±3.7)。使用膝关节协会评分(KSS)评估临床结果和PRO。术后3个月、1年和2年进行随访,包括临床检查、X线片、PRO评估和不良事件。使用视觉模拟量表(VAS,0(最差)至10(最佳))评估疼痛和满意度。为与TKA进行比较,进行倾向评分匹配对分析以消除混杂因素。匹配标准为性别、患者年龄、BMI和合并症。共分析了116对匹配对。
UKA组直到术后2年都没有翻修病例。TKA组的翻修率更高(0.6%)。UKA队列术前KSS评分更高(p<0.001)。手术治疗后,两个队列的患者报告结局测量(PROMs)均有显著改善(p<0.001)。关于膝关节评分(疼痛、对线、活动度),我们观察到12个月后两个队列之间没有差异。功能评分在UKA队列中显示出明显更好的结果(UKA与TKA分别为95和80,p<0.001)。UKA患者也有更高的患者满意度(UKA与TKA分别为9.0和8.8,p = 0.019)。
两个队列的患者在膝关节置换术后均表现出高满意度。与TKA相比,UKA在短期随访期间功能评分更高且翻修率未增加。因此,UKA是单髁OA的一种良好治疗选择。
Clinicaltrials.gov,NCT04598568。2020年10月22日注册——回顾性注册。