人类大脑在青春期和成年期的形态整合。
Morphological integration of the human brain across adolescence and adulthood.
机构信息
Harvard/MIT MD-PhD Program, Harvard Medical School, Boston, MA, 02115;
Section on Developmental Neurogenomics, National Institute of Mental Health, Bethesda, MD, 20892.
出版信息
Proc Natl Acad Sci U S A. 2021 Apr 6;118(14). doi: 10.1073/pnas.2023860118.
Brain structural covariance norms capture the coordination of neurodevelopmental programs between different brain regions. We develop and apply anatomical imbalance mapping (AIM), a method to measure and model individual deviations from these norms, to provide a lifespan map of morphological integration in the human cortex. In cross-sectional and longitudinal data, analysis of whole-brain average anatomical imbalance reveals a reproducible tightening of structural covariance by age 25 y, which loosens after the seventh decade of life. Anatomical imbalance change in development and in aging is greatest in the association cortex and least in the sensorimotor cortex. Finally, we show that interindividual variation in whole-brain average anatomical imbalance is positively correlated with a marker of human prenatal stress (birthweight disparity between monozygotic twins) and negatively correlated with general cognitive ability. This work provides methods and empirical insights to advance our understanding of coordinated anatomical organization of the human brain and its interindividual variation.
大脑结构协变规范捕捉到不同脑区之间神经发育程序的协调。我们开发并应用解剖不平衡映射（AIM）方法来测量和建模个体对这些规范的偏差，从而提供人类大脑皮质形态整合的终生图谱。在横断面和纵向数据中，全脑平均解剖不平衡的分析揭示了 25 岁之前结构协变的可重复收紧，之后在生命的第七个十年后开始放松。在发育和衰老过程中，解剖不平衡的变化在联合皮质中最大，在感觉运动皮质中最小。最后，我们表明全脑平均解剖不平衡的个体间变化与人类产前应激的标志物（同卵双胞胎之间的出生体重差异）呈正相关，与一般认知能力呈负相关。这项工作提供了方法和经验见解，以推进我们对人类大脑协调的解剖组织及其个体间变异性的理解。
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