St-Onge Frédéric, Javanray Mohammadali, Pichet Binette Alexa, Strikwerda-Brown Cherie, Remz Jordana, Spreng R Nathan, Shafiei Golia, Misic Bratislav, Vachon-Presseau Étienne, Villeneuve Sylvia
Integrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, Canada.
Research Center of the Douglas Mental Health University Institute, Montreal, Canada.
Netw Neurosci. 2023 Oct 1;7(3):1206-1227. doi: 10.1162/netn_a_00320. eCollection 2023.
Systematic changes have been observed in the functional architecture of the human brain with advancing age. However, functional connectivity (FC) is also a powerful feature to detect unique "connectome fingerprints," allowing identification of individuals among their peers. Although fingerprinting has been robustly observed in samples of young adults, the reliability of this approach has not been demonstrated across the lifespan. We applied the fingerprinting framework to the Cambridge Centre for Ageing and Neuroscience cohort ( = 483 aged 18 to 89 years). We found that individuals are "fingerprintable" (i.e., identifiable) across independent functional MRI scans throughout the lifespan. We observed a U-shape distribution in the strength of "self-identifiability" (within-individual correlation across modalities), and "others-identifiability" (between-individual correlation across modalities), with a decrease from early adulthood into middle age, before improving in older age. FC edges contributing to self-identifiability were not restricted to specific brain networks and were different between individuals across the lifespan sample. Self-identifiability was additionally associated with regional brain volume. These findings indicate that individual participant-level identification is preserved across the lifespan despite the fact that its components are changing nonlinearly.
随着年龄的增长，已观察到人类大脑功能结构的系统性变化。然而，功能连接性（FC）也是检测独特“连接组指纹”的强大特征，能够在同龄人中识别个体。尽管在年轻成年人样本中已有力地观察到指纹识别现象，但这种方法在整个生命周期中的可靠性尚未得到证实。我们将指纹识别框架应用于剑桥衰老与神经科学中心队列（n = 483，年龄在18至89岁之间）。我们发现，在整个生命周期内，个体在独立的功能磁共振成像扫描中是“可指纹识别的”（即可识别的）。我们观察到“自我识别性”（跨模态的个体内相关性）和“他人识别性”（跨模态的个体间相关性）的强度呈U形分布，从成年早期到中年有所下降，之后在老年期有所改善。对自我识别性有贡献的FC边缘并不局限于特定的脑网络，并且在整个生命周期样本中的个体之间存在差异。自我识别性还与区域脑容量相关。这些发现表明，尽管个体参与者层面识别的组成部分在非线性变化，但在整个生命周期中其识别能力得以保留。
