Department of Molecular Medicine and Genetics, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pathology and Laboratory Medicine, Western University, London, ON N6A 3K7, Canada; Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Life Sci. 2021 Jul 15;277:119451. doi: 10.1016/j.lfs.2021.119451. Epub 2021 Mar 31.
The Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS) continues to be a major global public health issue, having claimed almost 33 million lives so far. According to the recent report of the World Health Organization (WHO) in 2019, about 38 million people are living with AIDS. Hence, finding a solution to overcome this life-threatening virus can save millions of lives. Scientists and medical doctors have prescribed HIV patients with specific drugs for many years. Methods such antiretroviral therapy (ART) or latency-reversing agents (LRAs) have been used for a while to treat HIV patients, however they have some side effects and drawbacks causing their application to be not quite successful. Instead, the application of gene therapy which refers to the utilization of the therapeutic delivery of nucleic acids into a patient's cells as a drug to treat disease has shown promising results to control HIV infection. Therefore, in this review, we will summarize recent advances in gene therapy approach against HIV.
人类免疫缺陷病毒（HIV）/获得性免疫缺陷综合征（AIDS）仍然是一个主要的全球公共卫生问题，迄今为止已夺走近 3300 万人的生命。根据世界卫生组织（WHO）2019 年的最新报告，约有 3800 万人患有艾滋病。因此，找到一种克服这种危及生命的病毒的方法可以挽救数百万人的生命。多年来，科学家和医生为 HIV 患者开了特定的药物。抗逆转录病毒疗法（ART）或潜伏逆转剂（LRA）等方法已经被用于治疗 HIV 患者一段时间，但它们有一些副作用和缺点，导致它们的应用不太成功。相反，基因治疗的应用，即利用治疗性核酸递送至患者细胞作为药物来治疗疾病，已显示出控制 HIV 感染的有希望的结果。因此，在这篇综述中，我们将总结针对 HIV 的基因治疗方法的最新进展。
