Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam.
Faculty of Pharmacy, Duy Tan University, Da Nang 550000, Vietnam.
Ann Glob Health. 2021 Mar 24;87(1):28. doi: 10.5334/aogh.3163.
Previous studies reported the recurrence of coronavirus disease 2019 (COVID-19) among discharge patients. This study aimed to examine the characteristic of COVID-19 recurrence cases by performing a systematic review and meta-analysis.
A systematic search was performed in PubMed and Embase and gray literature up to September 19, 2020. A random-effects model was applied to obtain the pooled prevalence of disease recurrence among recovered patients and the prevalence of subjects underlying comorbidity among recurrence cases. The other characteristics were calculated based on the summary data of individual studies.
A total of 41 studies were included in the final analysis, we have described the epidemiological characteristics of COVID-19 recurrence cases. Of 3,644 patients recovering from COVID-19 and being discharged, an estimate of 15% (95% CI, 12% to 19%) patients was re-positive with SARS-CoV-2 during the follow-up. This proportion was 14% (95% CI, 11% to 17%) for China and 31% (95% CI, 26% to 37%) for Korea. Among recurrence cases, it was estimated 39% (95% CI, 31% to 48%) subjects underlying at least one comorbidity. The estimates for times from disease onset to admission, from admission to discharge, and from discharge to RNA positive conversion were 4.8, 16.4, and 10.4 days, respectively.
This study summarized up-to-date evidence from case reports, case series, and observational studies for the characteristic of COVID-19 recurrence cases after discharge. It is recommended to pay attention to follow-up patients after discharge, even if they have been in discharge quarantine.
先前的研究报告了出院患者中 2019 年冠状病毒病（COVID-19）的复发。本研究旨在通过系统评价和荟萃分析来检查 COVID-19 复发病例的特征。
对 PubMed 和 Embase 以及灰色文献进行了系统搜索，截止日期为 2020 年 9 月 19 日。应用随机效应模型获得已康复患者疾病复发的汇总患病率以及复发病例中合并症患者的患病率。其他特征根据单个研究的汇总数据计算。
共有 41 项研究纳入最终分析，我们描述了 COVID-19 复发病例的流行病学特征。在 3644 例从 COVID-19 中康复并出院的患者中，估计有 15%（95%置信区间，12%至 19%）的患者在随访期间再次出现 SARS-CoV-2 阳性。中国的这一比例为 14%（95%置信区间，11%至 17%），韩国为 31%（95%置信区间，26%至 37%）。在复发病例中，估计有 39%（95%置信区间，31%至 48%）的患者至少存在一种合并症。从发病到入院、从入院到出院以及从出院到 RNA 阳性转换的时间估计分别为 4.8、16.4 和 10.4 天。
本研究总结了来自病例报告、病例系列和观察性研究的最新证据，说明了出院后 COVID-19 复发病例的特征。建议关注出院后的随访患者，即使他们已经处于出院隔离状态。
