Yuan Yan, Su Juan, Li Ji, Tao Juan, Kang Xiaojing, Wu Bin, Shan Shijun, Wang Xiaohui, Chen Xiang, Shen Minxue, Jiang Liyuan
The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China.
Front Nutr. 2021 Mar 17;8:615462. doi: 10.3389/fnut.2021.615462. eCollection 2021.
It is understudied how frequently adolescents use nutritional supplements (NS) and whether the corresponding behavior is associated with skin diseases that may cause unpleasant symptoms and disfigurement. The current study aimed to investigate the prevalence of NS use in Chinese college students and its association with inflammatory skin diseases. This was a university-based epidemiologic investigation that included 20,138 students who underwent dermatological examinations. A questionnaire survey was conducted to inquire about the use of NS along with related information. Skin diseases were diagnosed by dermatologists during the health examination. Logistic regression models were used for analysis. Adjusted odds ratios (aORs) were presented as the effect size. Survey responses from a total of 20,138 participants were analyzed. Specifically, 18.3% of the participants reported the use of NS in the past year. The use of vitamin C was most frequently reported, accounting for a proportion of 12.9%, followed by vitamin B and mineral supplements. The use of NS was found to be associated with female sex, Han ethnicity, higher annual household income, and a series of healthy lifestyles such as more physical activity, less second-hand smoke exposure, less alcohol consumption, and higher intake of milk and yogurt ( < 0.001). Participants with chronic urticaria (aOR = 1.3; 95% CI, 1.0-1.7), atopic dermatitis (aOR = 1.4; 95% CI, 1.2-1.6), or acne (aOR = 1.17; 95% CI, 1.04-1.31) were more likely to use NS, especially herbs (aOR = 2.7; 95% CI, 1.2-3.7), followed by vitamin B (aOR = 1.6; 95% CI, 1.2-2.0) and mineral supplements (aOR = 1.4; 95% CI, 1.0-2.0). College students with inflammatory skin diseases are more likely to use NS.
青少年使用营养补充剂（NS）的频率以及相应行为是否与可能导致不适症状和毁容的皮肤病相关，目前研究较少。本研究旨在调查中国大学生使用NS的患病率及其与炎症性皮肤病的关联。这是一项基于大学的流行病学调查，纳入了20138名接受皮肤科检查的学生。进行问卷调查以询问NS的使用情况及相关信息。皮肤科医生在健康检查期间诊断皮肤病。采用逻辑回归模型进行分析。调整后的比值比（aOR）作为效应量呈现。共分析了20138名参与者的调查回复。具体而言，18.3%的参与者报告在过去一年中使用过NS。维生素C的使用报告最为频繁，占比12.9%，其次是维生素B和矿物质补充剂。发现使用NS与女性、汉族、家庭年收入较高以及一系列健康生活方式相关，如更多的体育活动、更少的二手烟暴露、更少的酒精消费以及更高的牛奶和酸奶摄入量（<0.001）。患有慢性荨麻疹（aOR = 1.3；95%CI，1.0 - 1.7）、特应性皮炎（aOR = 1.4；95%CI，1.2 - 1.6）或痤疮（aOR = 1.17；95%CI，1.04 - 1.31）的参与者更有可能使用NS，尤其是草药（aOR = 2.7；95%CI，1.2 - 3.7），其次是维生素B（aOR = 1.6；95%CI，1.2 - 2.0）和矿物质补充剂（aOR = 1.4；95%CI，1.0 - 2.0）。患有炎症性皮肤病的大学生更有可能使用NS。
