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作为蛋白质、肽和其他治疗性分子载体的纳米颗粒

Nanoparticles as Carriers of Proteins, Peptides and Other Therapeutic Molecules.

作者信息

Pudlarz Agnieszka, Szemraj Janusz

机构信息

Department of Medical Biochemistry, Medical University of Lodz, Lodz, Poland.

出版信息

Open Life Sci. 2018 Oct 31;13:285-298. doi: 10.1515/biol-2018-0035. eCollection 2018 Jan.

Abstract

Nanoparticles have many applications both in industry and medicine. Depending upon their physical and chemical properties, they can be used as carriers of therapeutic molecules or as therapeutics. Nanoparticles are made of synthetic or natural polymers, lipids or metals. Their use allows for faster transport to the place of action, thus prolonging its presence in the body and limiting side effects. In addition, the use of such a drug delivery system protects the drug from rapid disintegration and elimination from the body. In recent years, the use of proteins and peptides as therapeutic molecules has grown significantly. Unfortunately, proteins are subject to enzymatic digestion and can cause unwanted immune response beyond therapeutic action. The use of drug carriers can minimize undesirable side effects and reduce the dose of medication needed to achieve the therapeutic effect. The current study presents the use of several selected drug delivery systems for the delivery of proteins, peptides and other therapeutic molecules.

摘要

纳米颗粒在工业和医学领域都都都很多应用。根据其物理和化学性质,它们可作为治疗性分子的载体或用作治疗剂。纳米颗粒由合成或天然聚合物、脂质或金属制成。它们的使用能够实现更快地运输到作用部位,从而延长其在体内的存在时间并限制副作用。此外,使用这种药物递送系统可保护药物免于快速分解和从体内消除。近年来,蛋白质和肽作为治疗性分子的使用显著增加。不幸的是,蛋白质会受到酶消化作用,并且可能在治疗作用之外引发不必要的免疫反应。使用药物载体可将不良副作用降至最低,并减少达到治疗效果所需的药物剂量。本研究介绍了几种选定的药物递送系统用于递送蛋白质、肽和其他治疗性分子的情况。

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