Hansen L A, Deteresa R, Tobias H, Alford M, Terry R D
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla 92093.
Am J Pathol. 1988 Jun;131(3):507-18.
With a computerized image-analysis apparatus for neocortical morphometry and chemical methods for evaluation of the cholinergic system, five brain specimens of Pick's disease (PD) were studied and the results compared to those from specimens of age-matched normal subjects and Alzheimer's disease (AD). The PD specimens showed major reductions in brain weight, frontal and temporal cortical thickness, and large neuron populations, compared with controls. Lesser reductions were seen in small neurons and thickness of the inferior parietal cortex. The authors found no relationship between age of onset or disease duration and either the degree of cortical thinning or neuron loss or the number of Pick bodies in the neocortex and hippocampus. PD specimens were more atrophic than AD brains, having lower brain weights and more fronto-temporal thinning. Large neurons were comparably reduced in the two conditions in the frontal and temporal lobes, but small neuron losses were greater in the PD midfrontal area. Only the AD cases showed loss of large neurons in the inferior parietal region. Levels of choline acetyltransferase were normal in PD and reduced in AD, whereas muscarinic receptor binding was decreased in both.
使用用于新皮质形态测量的计算机化图像分析设备以及评估胆碱能系统的化学方法，对五例匹克病（PD）脑标本进行了研究，并将结果与年龄匹配的正常受试者和阿尔茨海默病（AD）标本的结果进行了比较。与对照组相比，PD标本的脑重量、额叶和颞叶皮质厚度以及大神经元数量均有显著减少。顶下小叶皮质的小神经元和厚度减少程度较小。作者发现发病年龄或病程与皮质变薄程度、神经元丢失或新皮质和海马体中匹克小体的数量之间均无关联。PD标本比AD脑萎缩更严重，脑重量更低，额颞叶变薄更明显。额叶和颞叶的大神经元在两种情况下均有类似程度的减少，但PD额中部区域的小神经元丢失更严重。只有AD病例在顶下区域出现大神经元丢失。PD中胆碱乙酰转移酶水平正常，AD中则降低，而毒蕈碱受体结合在两者中均减少。
