Grill H J, Smith G P
Department of Psychology, University of Pennsylvania, Philadelphia 19104.
Am J Physiol. 1988 Jun;254(6 Pt 2):R853-6. doi: 10.1152/ajpregu.1988.254.6.R853.
The capacity of chronic decerebrate rats to reduce their intake of an orally infused sucrose solution in response to peripherally administered cholecystokinin octapeptide (CCK-8) was investigated. The sucrose intake of both 24-h food-deprived chronic decerebrate rats and pair-fed control rats was reduced by CCK-8 relative to the intake after desulfated CCK-8. The intake-reducing effect of CCK-8 in the chronic decerebrate rat provides compelling evidence that the caudal brain stem is of sufficient neural complexity to mediate this response. Although others have hypothesized that connections between the caudal brain stem and forebrain are required to mediate this effect(s) of CCK-8, our results demonstrate that these pathways are not necessary.
研究了慢性去大脑大鼠对外周给予八肽胆囊收缩素（CCK-8）作出反应时减少口服蔗糖溶液摄入量的能力。相对于给予去硫酸化CCK-8后的摄入量，CCK-8使24小时禁食的慢性去大脑大鼠和配对喂养的对照大鼠的蔗糖摄入量均减少。CCK-8对慢性去大脑大鼠的摄入量减少作用提供了令人信服的证据，表明延髓具有足够的神经复杂性来介导这种反应。尽管其他人曾假设延髓和前脑之间的连接是介导CCK-8这种作用所必需的，但我们的结果表明这些通路并非必需。
