Kaplan J M, Södersten P
Department of Clinical Neuroscience, Karolinska Institute, Huddinge, Sweden.
Neuroreport. 1994 Sep 8;5(14):1839-40. doi: 10.1097/00001756-199409080-00039.
To determine whether dopamine receptors in the brain stem can mediate inhibition of feeding behaviour male rats in which the forebrain was disconnected from the brain stem were studied. Such decerebrate rats do not approach food but display ingestive responses if infused intraorally with a 1 M solution of sucrose at 0.6 ml min-1. Intraperitoneal injection of 5 micrograms cholecystokinin octapeptide, a physiological satiety peptide, or 400 micrograms apomorphine, a dopamine D1-D2 receptor agonist, suppressed intake of the sucrose solution. The results support a role of brain stem dopamine receptors in the control of ingestive behaviour.
为了确定脑干中的多巴胺受体是否能介导对摄食行为的抑制作用，研究了前脑与脑干分离的雄性大鼠。这种去大脑的大鼠不会主动接近食物，但如果以0.6毫升/分钟的速度经口注入1M的蔗糖溶液，它们会表现出摄食反应。腹腔注射5微克的胆囊收缩素八肽（一种生理性饱腹感肽）或400微克的阿扑吗啡（一种多巴胺D1-D2受体激动剂）可抑制蔗糖溶液的摄入。这些结果支持脑干多巴胺受体在控制摄食行为中发挥作用。
